| Simultaneous analysis of gamma-hydroxybutyric acid, gamma-butyrolactone, and 1,4-butanediol by micellar electrokinetic chromatography. | |
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MedLine Citation:
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PMID: 11909651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A micellar electrokinetic chromatography (MEKC) method was optimised for simultaneous analysis of gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (BD). Best conditions for separation and baseline stability were achieved using a carrier electrolyte comprising 30.0mM sodium barbital and 150.0mM sodium dodecyl sulphate (SDS) at pH 10.2. Calibration functions were linear, giving correlation coefficients (r(2)) >0.998 for the three target compounds. Limits of detection (LOD) defined as three times the noise, were 5.1mg/l, 0.34 and 0.25g/l for GHB, GBL and BD, respectively. The repeatability of migration times and peak areas, expressed as the R.S.D. (n = 9) was better than 0.41 and 3.05%, respectively. Some casework samples were analysed using the optimised conditions. |
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Authors:
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Johan Dahlén; Thyrsa Vriesman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Forensic science international Volume: 125 ISSN: 0379-0738 ISO Abbreviation: Forensic Sci. Int. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-03-22 Completed Date: 2002-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902034 Medline TA: Forensic Sci Int Country: Ireland |
Other Details:
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Languages: eng Pagination: 113-9 Citation Subset: IM |
Affiliation:
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SKL-National Laboratory of Forensic Science, SE-581 94, Linköping, Sweden. drog@skl.police.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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analysis* Butylene Glycols / analysis* Chromatography, Micellar Electrokinetic Capillary / methods* Hydroxybutyrates / analysis* Solvents / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Butylene Glycols; 0/Hydroxybutyrates; 0/Solvents; 110-63-4/1,4-butanediol; 591-81-1/4-hydroxybutyric acid; 96-48-0/4-Butyrolactone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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