| Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome: a possible faulty IL-13 feedback loop. | |
| | |
MedLine Citation:
|
PMID: 16303333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T cells (depressed proliferation to alphaCD3 + alphaCD4) had decreased IL-13 production concomitant to aberrant Mphi activities ( upward arrow mTNFalpha, downward arrow IL-10) and consequent multiple organ failure (MOF). Decreased IL-13 levels in patients' T cell and diminished Mphi supernatant augmentation of healthy controls' T cell IL-13 production appeared concomitantly, suggesting patients' aberrant monokine levels might intensify in vivo T cell dysfunction severity. Patients' Mphi supernatants, which failed to augment controls' T cell IL-13 production, had depressed IL-1beta and lower induction of IL-18 than immunocompetent patients' Mphi, but combined addition of IL-1beta and IL-18 restored these Mphis' IL-13 enhancing activity. These data suggest that immunodepressed patients' aberrant monokine and depressed T cell IL-13 production are independent but synergistic contributors to emergence of MOF. |
| | |
Authors:
|
Krzysztof Laudanski; Asit De; Joanmarie Pellegrini; Carol Miller-Graziano |
Related Documents
:
|
22949403 - Erucin and benzyl isothiocyanate suppress growth of late stage primary human ovarian ca... 23348613 - Prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein tha... 21457483 - Glucosamine inhibits epithelial-to-mesenchymal transition and migration of retinal pigm... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-11-21 |
Journal Detail:
|
Title: Clinical immunology (Orlando, Fla.) Volume: 118 ISSN: 1521-6616 ISO Abbreviation: Clin. Immunol. Publication Date: 2006 Feb-Mar |
Date Detail:
|
Created Date: 2006-02-10 Completed Date: 2006-03-30 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 332-41 Citation Subset: IM |
Affiliation:
|
Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave.-SURG, Rochester, NY 14642, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Cells, Cultured Female Humans Interleukin-13 / antagonists & inhibitors*, biosynthesis, physiology* Interleukin-13 Receptor alpha1 Subunit Macrophages / immunology*, metabolism, pathology Male Middle Aged Monokines / metabolism Multiple Organ Failure / immunology, metabolism, pathology Receptors, Interleukin / metabolism Receptors, Interleukin-13 T-Lymphocytes / immunology*, metabolism Wounds and Injuries / immunology*, metabolism, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 GM36214/GM/NIGMS NIH HHS; R01 GM65237/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/IL13RA1 protein, human; 0/Interleukin-13; 0/Interleukin-13 Receptor alpha1 Subunit; 0/Monokines; 0/Receptors, Interleukin; 0/Receptors, Interleukin-13 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Giardia immunity--an update.
Next Document: Inflammatory modulation of PPAR gamma expression and activity.