Document Detail


Simultaneous aberrations in Mphi and T cell function adversely affect trauma patients' clinical outcome: a possible faulty IL-13 feedback loop.
MedLine Citation:
PMID:  16303333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Possible defective trauma patients' Mphi-T-cell feedback interactions between T cell IL-13 production and IL-1beta and IL-18 Mphi secretion were assessed. Mphi produced IL-1 and IL-18 augment T cell IL-13, which in turn limits excessive macrophage activation. Immunodepressed patients' T cells (depressed proliferation to alphaCD3 + alphaCD4) had decreased IL-13 production concomitant to aberrant Mphi activities ( upward arrow mTNFalpha, downward arrow IL-10) and consequent multiple organ failure (MOF). Decreased IL-13 levels in patients' T cell and diminished Mphi supernatant augmentation of healthy controls' T cell IL-13 production appeared concomitantly, suggesting patients' aberrant monokine levels might intensify in vivo T cell dysfunction severity. Patients' Mphi supernatants, which failed to augment controls' T cell IL-13 production, had depressed IL-1beta and lower induction of IL-18 than immunocompetent patients' Mphi, but combined addition of IL-1beta and IL-18 restored these Mphis' IL-13 enhancing activity. These data suggest that immunodepressed patients' aberrant monokine and depressed T cell IL-13 production are independent but synergistic contributors to emergence of MOF.
Authors:
Krzysztof Laudanski; Asit De; Joanmarie Pellegrini; Carol Miller-Graziano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2005-11-21
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  118     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:    2006 Feb-Mar
Date Detail:
Created Date:  2006-02-10     Completed Date:  2006-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-41     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Rochester Medical Center, 601 Elmwood Ave.-SURG, Rochester, NY 14642, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Cells, Cultured
Female
Humans
Interleukin-13 / antagonists & inhibitors*,  biosynthesis,  physiology*
Interleukin-13 Receptor alpha1 Subunit
Macrophages / immunology*,  metabolism,  pathology
Male
Middle Aged
Monokines / metabolism
Multiple Organ Failure / immunology,  metabolism,  pathology
Receptors, Interleukin / metabolism
Receptors, Interleukin-13
T-Lymphocytes / immunology*,  metabolism
Wounds and Injuries / immunology*,  metabolism,  pathology
Grant Support
ID/Acronym/Agency:
R01 GM36214/GM/NIGMS NIH HHS; R01 GM65237/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/IL13RA1 protein, human; 0/Interleukin-13; 0/Interleukin-13 Receptor alpha1 Subunit; 0/Monokines; 0/Receptors, Interleukin; 0/Receptors, Interleukin-13

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