| Simultaneous T(2) and lipid quantitation using IDEAL-CPMG. | |
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MedLine Citation:
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PMID: 21604292 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Muscle damage, edema, and fat infiltration are hallmarks of a range of neuromuscular diseases. The T(2) of water, T(2,w) , in muscle lengthens with both myocellular damage and inflammation and is typically measured using multiple spin-echo or Carr-Purcell-Meiboom-Gill acquisitions. However, microscopic fat infiltration in neuromuscular diseases prevents accurate T(2,w) quantitation as the longer T(2) of fat, T(2,f) , masks underlying changes in the water component. Fat saturation can be inconsistent across the imaging volume and removes valuable physiological fat information. A new method is presented that combines iterative decomposition of water and fat with echo asymmetry and least squares estimation with a Carr-Purcell-Meiboom-Gill-sequence. The sequence results in water and fat separated images at each echo time for use in T(2,w) and T(2,f) quantification. With knowledge of the T(2,w) and T(2,f) , a T(2) -corrected fat fraction map can also be calculated. Monte-Carlo simulations and measurements in phantoms, volunteers, and a patient with inclusion body myositis are demonstrated. In healthy volunteers, uniform T(2,w) and T(2) -corrected fat fraction maps are present within all muscle groups. However, muscle-specific patterns of fat infiltration and edema are evident in inclusion body myositis, which demonstrates the power of separating and quantifying the fat and water components. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Robert L Janiczek; Giulio Gambarota; Christopher D J Sinclair; Tarek A Yousry; John S Thornton; Xavier Golay; Rexford D Newbould |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-20 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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GSK Clinical Imaging Centre, Hammersmith Hospital, London, United Kingdom; Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom. rob.janiczek@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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