Document Detail


Simultaneous pulmonary and systemic blood pressure and ECG Interval measurement in conscious, freely moving rats.
MedLine Citation:
PMID:  22776124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we evaluated the ability of a new, dual blood-pressure telemetry transmitter to simultaneously measure pulmonary and systemic blood pressure and the electrocardiogram in rats. The transmitter was implanted in normotensive and monocrotaline-induced pulmonary hypertensive Wistar rats, with sensing catheters placed in the pulmonary artery (channel 1) and descending aorta (channel 2). Biopotential electrodes were positioned to record an apex-based lead II electrocardiogram. Pulmonary and systemic arterial blood pressure and electrocardiographic waveforms were recorded between 2 and 12 wk after implantation of the transmitter. During this period, pulmonary arterial pressure progressively increased in monocrotaline-treated compared with saline-treated rats. The pharmacologic response of rats to reference compounds was measured by using the transmitter to validate the technique and to evaluate the ability of the device to transmit changes in blood pressure and the electrocardiogram. Validation against 2 Millar high-fidelity blood-pressure catheters confirmed the accuracy of the blood pressure data recorded with the transmitter. In addition, local tolerance of the associated catheters was confirmed by histologic examination.
Authors:
Markus Rey; Edgar W Weber; Patrick D Hess
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American Association for Laboratory Animal Science : JAALAS     Volume:  51     ISSN:  1559-6109     ISO Abbreviation:  J. Am. Assoc. Lab. Anim. Sci.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-11-19     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101269489     Medline TA:  J Am Assoc Lab Anim Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-8     Citation Subset:  IM    
Affiliation:
Actelion Pharmaceuticals, Allschwil, Switzerland. markus.rey@actelion.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Blood Pressure Monitoring, Ambulatory / methods*,  veterinary
Catheters / veterinary
Electrocardiography, Ambulatory / methods*,  veterinary
Hypertension / chemically induced,  veterinary*
Male
Monocrotaline / toxicity*
Pulmonary Artery / physiology*
Rats
Rats, Wistar
Telemetry / methods,  veterinary
Chemical
Reg. No./Substance:
315-22-0/Monocrotaline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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