| Simultaneous GLC determination of clofibrate and clofibric acid in human plasma. | |
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MedLine Citation:
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PMID: 7354454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simultaneous assay for the detection of clofibrate and its metabolite, clofibric acid [2-(p-chlorophenoxy)-2-methylpropionic acid], is described. This GLC method is rapid and does not require a derivatization step. It is sensitive to 1-microgram/ml levels of either compound in biological samples and can be used to characterize the in vivo conversion of clofibrate ester to the free acid. |
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Authors:
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M S Wolf; J J Zimmerman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 69 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-17 Completed Date: 1980-04-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 92-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gas Clofibrate / analogs & derivatives*, blood* Clofibric Acid / blood* Humans Hydrolysis |
| Chemical | |
Reg. No./Substance:
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637-07-0/Clofibrate; 882-09-7/Clofibric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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