| Simultaneous Absolute Measures of Glabrous Skin Hemodynamic and Light-Scattering Change in Response to Formalin Injection in Rats. | |
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MedLine Citation:
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PMID: 21281696 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Subcutaneous injection of formalin is a well-known model to study the nature of inflammatory pain. One of the cardinal signs of inflammation is redness, as a result of increased blood perfusion. We used an optical technology, light reflectance spectroscopy, to noninvasively obtain absolute measures of cutaneous hemodynamic components, including the concentrations of oxy- ([HbO]), deoxy- ([Hb]), total-hemoglobin ([HbT]), oxygen saturation (SO2), and the reduced light-scattering coefficient (μs'). The objective is to assess the effect of formalin-induced skin inflammation on the aforementioned parameters. Six rats were injected with formalin (50μl, 3%) into left hind paw under pentobarbital anesthesia. Our results indicate prolonged increases in [HbO], [HbT], and SO2 post injection only in the ipsilateral side. No statistically significant changes in [Hb] and μs' occurred in either side. The arterial blood influx tends to be the major attribute of local hyperemia during inflammation. Thereby, [HbO] appears to be superior to [Hb] in measuring inflammation. In conclusion, the needle-probe-based light reflectance can be a feasible means to obtaining absolute measures of skin hemodynamic and light-scattering parameters when studying inflammatory pain. |
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Authors:
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Ji-Wei He; Dheerendra Kashyap; Lara A Trevino; Hanli Liu; Yuan Bo Peng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-28 |
Journal Detail:
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Title: Neuroscience letters Volume: - ISSN: 1872-7972 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Psychology, College of Science, University of Texas at Arlington, Arlington, Texas 76019. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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