| Simulations of methylene chloride pharmacokinetics using a physiologically based model. | |
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MedLine Citation:
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PMID: 6441198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of the solvent methylene chloride have been studied using a physiologically based model that was developed for iv administrations to mice. Subsequently, the model was expanded to simulate pharmacokinetic behavior in mice and rats following single and repeated oral exposures. Through computer simulations, how different dosing variables, such as dose vehicle and exposure route, could influence the time course of methylene chloride concentrations at potentially critical sites of toxicity was examined. With this technique, methods of quantifying tissue exposure as it relates to externally applied doses was sought. In this way pharmacokinetic models help investigators design experiments that lead to more appropriate and reliable toxicologic assessment studies. |
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Authors:
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M J Angelo; A B Pritchard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Regulatory toxicology and pharmacology : RTP Volume: 4 ISSN: 0273-2300 ISO Abbreviation: Regul. Toxicol. Pharmacol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-03-21 Completed Date: 1985-03-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8214983 Medline TA: Regul Toxicol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 329-39 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / metabolism Corn Oil Hydrocarbons, Chlorinated / metabolism* Injections, Intravenous Intestinal Absorption Kinetics Liver / metabolism Methylene Chloride / administration & dosage, metabolism* Mice Models, Biological Oils Regional Blood Flow Vehicles |
| Chemical | |
Reg. No./Substance:
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0/Hydrocarbons, Chlorinated; 0/Oils; 0/Vehicles; 124-38-9/Carbon Dioxide; 75-09-2/Methylene Chloride; 8001-30-7/Corn Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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