Document Detail

Simulation of therapeutic parent artery occlusion for basilar head aneurysms. Hemodynamic effect of occlusion sites and diameters of collateral arteries.
MedLine Citation:
PMID:  10100205     Owner:  NLM     Status:  MEDLINE    
We simulated parent artery occlusion therapy for basilar head aneurysms to elucidate the hemodynamic changes induced by different occlusion sites and diameters of the posterior communicating arteries (PCom) as collateral pathways. A vascular model of the vertebrobasilar system with a basilar head aneurysm was constructed. Four types of occlusion were simulated: Basilar artery occlusion distal to (Type A), between (Type B) and proximal to (Type C) the superior cerebellar arteries, and bilateral vertebral artery occlusion (Type D). Glycerol solution was perfused into the model, and the half-life of the dye injected into the aneurysm was calculated and regarded as an index of stagnant flow in the aneurysm. The half-life was increased significantly and nonlinearly after parent artery occlusion, depending on the occlusion site and the ratio of two PCom diameters (diameter ratio). Intra-aneurysmal stagnation developed markedly in Type A and Type B in the diameter ratio higher than 0.70 and considerably in Type C in the ratio higher than 0.80. Additional P1 occlusion of the posterior cerebral artery enhanced the stagnation in Type A and B. Since the results are consistent with the published clinical data, the simulation study will be useful for speculating the efficacy of the therapeutic occlusion.
S Nagasawa; M Kawanishi; Y Tada; S Kawabata; T Ohta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  21     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  180-4     Citation Subset:  IM    
Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan.
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MeSH Terms
Basilar Artery*
Collateral Circulation / physiology*
Coloring Agents
Computer Simulation*
Hemodynamics / physiology*
Intracranial Aneurysm / therapy*
Models, Neurological*
Reg. No./Substance:
0/Coloring Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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