| Simulation studies of the ischemic vulnerability of the subendocardium. | |
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MedLine Citation:
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PMID: 11575462 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in the subendo-subepi flow ratio were studied by using a simple electronic circuit model of the coronary vessel consisting of a resistor, capacitor and field effect transistor in order to provide a better understanding of the ischemic vulnerability of the subendocardium. The simulated subendo-subepi flow ratio was found to be approximately 1.2 under normal condition. Changes in the flow ratio were observed while varying the main arterial resistance, mean arterial pressure and intramyocardial pressure individually. The mean flow in the subendocardium was found to decrease at a rate faster than that in the subepicardium with the increase in the septal arterial resistance and the intramyocardial pressure. The same tendency was also observed while the arterial pressure was lowered. This decrease in the mean subendocardial flow is considered to be the effect of higher end-systolic resistance in the subendocardial venule compared to that in the subepicardial venule. These results would be helpful in understanding the vulnerability of the subendocardium to ischemia and in providing clinical treatment to patients with that disease. |
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Authors:
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T Ejaz; T Takemae; Y Kosugi; M Hongo |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering Volume: 11 ISSN: 0921-3775 ISO Abbreviation: Front Med Biol Eng Publication Date: 2001 |
Date Detail:
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Created Date: 2001-09-28 Completed Date: 2002-03-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9011464 Medline TA: Front Med Biol Eng Country: Netherlands |
Other Details:
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Languages: eng Pagination: 103-15 Citation Subset: IM |
Affiliation:
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Graduate School of Electronic Science and Technology, Shijuoka University Faculty of Engineering, Hamamatsu, Japan. ejaz@mail.vbl.shizuoka.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electronics Electrophysiology Endocardium / pathology*, physiology* Humans Ischemia* Models, Theoretical Myocardium / metabolism Pressure Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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