Document Detail


Simulation of portal hemodynamic changes in a donor after right hepatectomy.
MedLine Citation:
PMID:  20387965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Remnant livers will be regenerated in live donors after a large volume resection for transplantation. How the structures and hemodynamics of portal vein will evolve with liver regeneration remains unknown. This prompts the present hemodynamic simulation for a 25 year-old man who received a right donor lobectomy. According to the magnetic resonance imaging/computed tomography images taken prior to the operation and one month after the operation, three sequential models of portal veins (pre-op, immediately after the operation, and one-month post-op) were constructed by AMIRA and HYPERMESH, while the immediately after the operation model was generated by removing the right branch in the pre-op model. Hemodynamic equations were solved subject to the sonographically measured inlet velocity. The simulated branch velocities were compared with the measured ones. The predicted overall pressure in the portal vein after resection was found to increase to a magnitude that has not reached to an extent possibly leading to portal hypertension. As expected, blood pressure has a large change only in the vicinity of the resection region. The branches grew considerably different from the original one as the liver is regenerated. Results provide useful evidence to justify the current computer simulation.
Authors:
Cheng-Maw Ho; Reui-Kuo Lin; Shun-Feng Tsai; Rey-Hen Hu; Po-Chin Liang; Tony Wen-Hann Sheu; Po-Huang Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  132     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  041002     Citation Subset:  IM    
Affiliation:
Department of Surgery, National Taiwan University Hospital, Taipei, 100 Taiwan, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Computer Simulation
Hepatectomy*
Humans
Liver / blood supply,  physiopathology*,  surgery*
Liver Circulation*
Models, Cardiovascular*
Portal Vein / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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