| Simulation of the Frank-Starling Law of the Heart. | |
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MedLine Citation:
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PMID: 23243461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload). The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology. |
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Authors:
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Samo Ribarič; Marjan Kordaš |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-11-29 |
Journal Detail:
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Title: Computational and mathematical methods in medicine Volume: 2012 ISSN: 1748-6718 ISO Abbreviation: Comput Math Methods Med Publication Date: 2012 |
Date Detail:
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Created Date: 2012-12-17 Completed Date: 2013-03-28 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101277751 Medline TA: Comput Math Methods Med Country: United States |
Other Details:
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Languages: eng Pagination: 267834 Citation Subset: IM |
Affiliation:
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Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1104 Ljubljana, Slovenia. samo.ribaric@mf.uni-lj.si |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Pressure Blood Pressure Computational Biology / methods Computer Simulation Electrophysiology / methods Heart / physiology Heart Atria / metabolism Heart Ventricles / metabolism Humans Models, Biological Models, Cardiovascular* Myocardial Contraction / physiology* Myocardium / metabolism Pressure Ranidae |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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