Document Detail

Simulation of the Frank-Starling Law of the Heart.
MedLine Citation:
PMID:  23243461     Owner:  NLM     Status:  MEDLINE    
We developed a lumped parameter, computer-based model of an equivalent electronic circuit for a one-atrium one-ventricle (frog) heart attached to a vascular circuit, to simulate a basic concept of cardiovascular physiology, the Frank-Starling Law of the Heart. A series of simulations was performed, to observe changes in cardiovascular variables (e.g., arterial pressure, ventricular volume, and valve flows) if either preload or afterload was increased. The simulated data agreed qualitatively, and quantitatively when experimental data are available, with data obtained on amphibian or on mammalian myocardium. In addition, the data obtained in these simulations improve our understanding of the mechanism(s) whereby the heart muscle adapts itself to increased distension (increased preload) or to impeded systolic contraction (increased afterload). The analysis of the measured valve flows suggests that the ventricle is a highly input sensitive pump because the input pressure determines the diastolic distension and, consequently, the force of ventricular systolic contraction. On the other hand, the ventricle is a relatively output insensitive pump. Therefore, not only atrium contraction, but also predominantly the preceding ventricular systolic contraction is the main mechanism of the subsequent diastolic ventricular filling. We conclude that the presented model enables the study of basic concepts of cardiovascular physiology.
Samo Ribarič; Marjan Kordaš
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-29
Journal Detail:
Title:  Computational and mathematical methods in medicine     Volume:  2012     ISSN:  1748-6718     ISO Abbreviation:  Comput Math Methods Med     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-03-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101277751     Medline TA:  Comput Math Methods Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267834     Citation Subset:  IM    
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, 1104 Ljubljana, Slovenia.
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MeSH Terms
Arterial Pressure
Blood Pressure
Computational Biology / methods
Computer Simulation
Electrophysiology / methods
Heart / physiology
Heart Atria / metabolism
Heart Ventricles / metabolism
Models, Biological
Models, Cardiovascular*
Myocardial Contraction / physiology*
Myocardium / metabolism

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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