| Simulation of cardiac motion on non-Newtonian, pulsating flow development in the human left anterior descending coronary artery. | |
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MedLine Citation:
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PMID: 18711245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed at investigating the effect of myocardial motion on pulsating blood flow distribution of the left anterior descending coronary artery in the presence of atheromatous stenosis. The moving 3D arterial tree geometry has been obtained from conventional x-ray angiograms obtained during the heart cycle and includes a number of major branches. The geometry reconstruction model has been validated against projection data from a virtual phantom arterial tree as well as with CT-based reconstruction data for the same patient investigated. Reconstructions have been obtained for a number of temporal points while linear interpolation has been used for all intermediate instances. Blood has been considered as a non-Newtonian fluid. Results have been obtained using the same pulse for the inlet blood flow rate but with fixed arterial tree geometry as well as under steady-state conditions corresponding to the mean flow rate. Predictions indicate that myocardial motion has only a minor effect on flow distribution within the arterial tree relative to the effect of the blood pressure pulse. |
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Authors:
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A Theodorakakos; M Gavaises; A Andriotis; A Zifan; P Liatsis; I Pantos; E P Efstathopoulos; D Katritsis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-18 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 53 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-27 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 4875-92 Citation Subset: IM |
Affiliation:
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Fluid Research Co., Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / physiology* Computer Simulation Coronary Circulation / physiology* Coronary Vessels / physiology* Heart / physiology* Humans Models, Cardiovascular* Movement / physiology* Nonlinear Dynamics Pulsatile Flow / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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