| Simulation of blood flow in a small-diameter vascular graft model with a swirl (spiral) flow guider. | |
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MedLine Citation:
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PMID: 18815755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small-diameter vascular grafts are in large demand for coronary and peripheral bypass procedures, but present products still fail in long-term clinical application. In the present communication, a new type of small-diameter graft with a swirl flow guider was proposed to improve graft patency rate. Flow pattern in the graft was simulated numerically and compared with that in a conventional graft. The numerical results revealed that the swirl flow guider could indeed make the blood flow rotate in the new graft. The swirling flow distal to the flow guider significantly altered the flow pattern in the new graft and the velocity profiles were re-distributed. Due to the swirling flow, the blood velocity near the vessel wall and wall shear rate were greatly enhanced. We believe that the increased blood velocity near the wall and the wall shear rate can impede the occurrence of acute thrombus formation and intimal hyperplasia, hence can improve the graft patency rate for long-term clinical use. |
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Authors:
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ZhiGuo Zhang; YuBo Fan; XiaoYan Deng; GuiXue Wang; He Zhang; Robert Guidoin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-26 |
Journal Detail:
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Title: Science in China. Series C, Life sciences / Chinese Academy of Sciences Volume: 51 ISSN: 1006-9305 ISO Abbreviation: Sci. China, C, Life Sci. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-25 Completed Date: 2008-12-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9611809 Medline TA: Sci China C Life Sci Country: China |
Other Details:
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Languages: eng Pagination: 913-21 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, Beihang University, Beijing, 100083, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Blood Vessel Prosthesis* Computer Simulation Models, Biological* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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