Document Detail

Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model.
MedLine Citation:
PMID:  22949359     Owner:  NLM     Status:  MEDLINE    
In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann's bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction.
Dong-dong Deng; Ying-lan Gong; Guo-fa Shou; Pei-feng Jiao; Heng-gui Zhang; Xue-song Ye; Ling Xia
Related Documents :
19486989 - Comparative multiple quantitative structure-retention relationships modeling of gas chr...
16288769 - Quantitative study of the structure-retention index relationship in the imine family.
17405109 - Computational chemistry development of a unified free energy markov model for the distr...
11386859 - Mathematical programming assisted drug design for nonclassical antifolates.
10850779 - Prediction of inhibition of the sodium ion-proton antiporter by benzoylguanidine deriva...
15267239 - Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acet...
21096419 - Non-parametric kernel density estimation for the prediction of neoadjuvant chemotherapy...
25447439 - Modelling microbial dechlorination of trichloroethene: investigating the trade-off betw...
16405139 - Using the score method to construct asymmetric confidence intervals: an sas program for...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  13     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-02-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  676-94     Citation Subset:  IM    
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atrial Function / physiology*
Biomedical Engineering
Computer Simulation*
Coronary Sinus / physiology
Electrophysiological Phenomena
Heart Atria / cytology
Heart Conduction System / physiology*
Models, Cardiovascular*
Sinoatrial Node / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular biomarkers of colorectal cancer: prognostic and predictive tools for clinical practice.
Next Document:  Impairment of liver regeneration by the histone deacetylase inhibitor valproic acid in mice.