Document Detail

Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model.
MedLine Citation:
PMID:  22949359     Owner:  NLM     Status:  MEDLINE    
In order to better understand biatrial conduction, investigate various conduction pathways, and compare the differences between isotropic and anisotropic conductions in human atria, we present a simulation study of biatrial conduction with known/assumed conduction pathways using a recently developed human atrial model. In addition to known pathways: (1) Bachmann's bundle (BB), (2) limbus of fossa ovalis (LFO), and (3) coronary sinus (CS), we also hypothesize that there exist two fast conduction bundles that connect the crista terminalis (CT), LFO, and CS. Our simulation demonstrates that use of these fast conduction bundles results in a conduction pattern consistent with experimental data. The comparison of isotropic and anisotropoic conductions in the BB case showed that the atrial working muscles had small effect on conduction time and conduction speed, although the conductivities assigned in anisotropic conduction were two to four times higher than the isotropic conduction. In conclusion, we suggest that the hypothesized intercaval bundles play a significant role in the biatrial conduction and that myofiber orientation has larger effects on the conduction system than the atrial working muscles. This study presents readers with new insights into human atrial conduction.
Dong-dong Deng; Ying-lan Gong; Guo-fa Shou; Pei-feng Jiao; Heng-gui Zhang; Xue-song Ye; Ling Xia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  13     ISSN:  1862-1783     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-02-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  676-94     Citation Subset:  IM    
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
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MeSH Terms
Atrial Function / physiology*
Biomedical Engineering
Computer Simulation*
Coronary Sinus / physiology
Electrophysiological Phenomena
Heart Atria / cytology
Heart Conduction System / physiology*
Models, Cardiovascular*
Sinoatrial Node / physiology

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