| Simulation of the three-dimensional hinge flow fields of a bileaflet mechanical heart valve under aortic conditions. | |
| | |
MedLine Citation:
|
PMID: 19960368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Thromboembolic complications of bileaflet mechanical heart valves (BMHV) are believed to be due to detrimental stresses imposed on blood elements by the hinge flows. Characterization of these flows is thus crucial to identify the underlying causes for complications. In this study, we conduct three-dimensional pulsatile flow simulations through the hinge of a BMHV under aortic conditions. Hinge and leaflet geometries are reconstructed from the Micro-Computed Tomography scans of a BMHV. Simulations are conducted using a Cartesian sharp-interface immersed-boundary methodology combined with a second-order accurate fractional-step method. Physiologic flow boundary conditions and leaflet motion are extracted from the Fluid-Structure Interaction simulations of the bulk of the flow through a BMHV. Calculations reveal the presence, throughout the cardiac cycle, of flow patterns known to be detrimental to blood elements. Flow fields are characterized by: (1) complex systolic flows, with rotating structures and slow reverse flow pattern, and (2) two strong diastolic leakage jets accompanied by fast reverse flow at the hinge bottom. Elevated shear stresses, up to 1920 dyn/cm2 during systole and 6115 dyn/cm2 during diastole, are reported. This study underscores the need to conduct three-dimensional simulations throughout the cardiac cycle to fully characterize the complexity and thromboembolic potential of the hinge flows. |
| | |
Authors:
|
Hélène A Simon; Liang Ge; Iman Borazjani; Fotis Sotiropoulos; Ajit P Yoganathan |
Related Documents
:
|
8212968 - Does aortic regurgitation affect transmitral flow? an echo-doppler study. 15636108 - Three-dimensional fluid-structure interaction simulation of bileaflet mechanical heart ... 8382088 - Blood haemolysis by ceramics. 18001008 - Automated control of local solution environments in open-volume microfluidics. 6230368 - Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before p... 699718 - Nucleoli in lymphocytes of the peripheral blood in hodgkin's disease: i. changes in the... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-12-04 |
Journal Detail:
|
Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-03-18 Completed Date: 2010-06-30 Revised Date: 2010-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
|
Languages: eng Pagination: 841-53 Citation Subset: IM |
Affiliation:
|
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0535, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aortic Valve
/
physiology*,
surgery* Blood Flow Velocity Computer Simulation Equipment Failure Analysis Heart Valve Prosthesis* Humans Models, Cardiovascular* |
| Grant Support | |
ID/Acronym/Agency:
|
R01-HL-070262/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Erratum In:
|
Ann Biomed Eng. 2010 Mar;38(3):1257 Note: Borazjani, Iman [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Zinc triflate: a highly efficient reusable catalyst in the synthesis of functionalized quinolines vi...
Next Document: Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituita...