Document Detail


Simulating realistic zero loop pedigrees using a bipartite Prufer code and graphical modelling.
MedLine Citation:
PMID:  15567888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Graph algorithms previously developed by the authors are adapted to simulate pedigrees similar to those used in genetic linkage studies which associate disease phenotypes with specific genomic locations. Pedigrees are chosen uniformly at random from the set of those with specified numbers of individuals and matings and which contain no loops. Summary statistics from pedigrees generated in this way can be used to check real pedigrees for anomalies due to biased sampling or phenotypic effects on the pedigree structure.
Authors:
Alun Thomas; Chris Cannings
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mathematical medicine and biology : a journal of the IMA     Volume:  21     ISSN:  1477-8599     ISO Abbreviation:  Math Med Biol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-29     Completed Date:  2005-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182345     Medline TA:  Math Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  335-45     Citation Subset:  IM    
Affiliation:
Department of Medical Informatics and Center for High Performance Computing, University of Utah, 391 Chipeta Way Suite D, Salt Lake City, UT 84108, USA. alun@genepi.med.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Female
Humans
Linkage (Genetics)*
Male
Models, Genetic*
Pedigree*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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