Document Detail

Simulating human cones from mid-mesopic up to high-photopic luminances.
MedLine Citation:
PMID:  17461685     Owner:  NLM     Status:  MEDLINE    
A computational model of human cones for intensities ranging from 1 td up to full bleaching levels is presented. The model conforms well with measurements made in primate horizontal cells, follows Weber's law at high intensities, and performs range compression consistent with what is known of cones in other vertebrates. The model consists entirely of processes with a clear physiological interpretation: pigment bleaching, saturation of cGMP hydrolysis, calcium feedback on cGMP synthesis, and a nonlinear membrane. The model is implemented according to a very fast computational scheme useful for simulations, and sample programs in Matlab and Fortran are provided as supplementary material.
J H van Hateren; H P Snippe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-05
Journal Detail:
Title:  Journal of vision     Volume:  7     ISSN:  1534-7362     ISO Abbreviation:  J Vis     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-05-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101147197     Medline TA:  J Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1     Citation Subset:  IM    
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
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MeSH Terms
Adaptation, Physiological
Calcium / metabolism
Computer Simulation*
Contrast Sensitivity / physiology
Cyclic GMP / biosynthesis,  metabolism
Feedback, Physiological
Membranes / physiology
Models, Neurological*
Nonlinear Dynamics
Photic Stimulation / methods
Retinal Cone Photoreceptor Cells / metabolism,  physiology*,  radiation effects*
Retinal Horizontal Cells / physiology
Retinal Pigments / physiology
Reg. No./Substance:
0/Retinal Pigments; 7440-70-2/Calcium; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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