| Simulating efficiently the evolution of DNA sequences. | |
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MedLine Citation:
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PMID: 7796269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two menu-driven FORTRAN programs are described that simulate the evolution of DNA sequences in accordance with a user-specified model. This general stochastic model allows for an arbitrary stationary nucleotide composition and any transition-transversion bias during the process of base substitution. In addition, the user may define any hypothetical model tree according to which a family of sequences evolves. The programs suggest the computationally most inexpensive approach to generate nucleotide substitutions. Either reproducible or non-repeatable simulations, depending on the method of initializing the pseudo-random number generator, can be performed. The corresponding options are offered by the interface menu. |
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Authors:
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M Schöniger; A von Haeseler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Computer applications in the biosciences : CABIOS Volume: 11 ISSN: 0266-7061 ISO Abbreviation: Comput. Appl. Biosci. Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-08-03 Completed Date: 1995-08-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8511758 Medline TA: Comput Appl Biosci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 111-5 Citation Subset: IM |
Affiliation:
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Technical University Munich, Garching, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Base Sequence Computer Simulation* DNA / genetics* Evaluation Studies as Topic Evolution* Models, Genetic Phylogeny Software* Stochastic Processes |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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