Document Detail

Simulating efficiently the evolution of DNA sequences.
MedLine Citation:
PMID:  7796269     Owner:  NLM     Status:  MEDLINE    
Two menu-driven FORTRAN programs are described that simulate the evolution of DNA sequences in accordance with a user-specified model. This general stochastic model allows for an arbitrary stationary nucleotide composition and any transition-transversion bias during the process of base substitution. In addition, the user may define any hypothetical model tree according to which a family of sequences evolves. The programs suggest the computationally most inexpensive approach to generate nucleotide substitutions. Either reproducible or non-repeatable simulations, depending on the method of initializing the pseudo-random number generator, can be performed. The corresponding options are offered by the interface menu.
M Schöniger; A von Haeseler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Computer applications in the biosciences : CABIOS     Volume:  11     ISSN:  0266-7061     ISO Abbreviation:  Comput. Appl. Biosci.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8511758     Medline TA:  Comput Appl Biosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Technical University Munich, Garching, Germany.
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MeSH Terms
Base Sequence
Computer Simulation*
DNA / genetics*
Evaluation Studies as Topic
Models, Genetic
Stochastic Processes
Reg. No./Substance:

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