| Simulating activity of the bacterial ribosome. | |
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MedLine Citation:
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PMID: 20450532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Computational modeling studies that investigate activity of the bacterial ribosome were reviewed. Computational approaches became possible with the availability of three-dimensional atomic resolution structures of the ribosomal subunits. However, due to the enormous size of the system, theoretical efforts to study the ribosome are few and challenging. For example, to extend the simulation timescales to biologically relevant ones, often, reduced models that require tedious parameterizations need to be applied. To that end, modeling of the ribosome focused on its internal dynamics, electrostatic properties, inhibition by antibiotics, polypeptide folding in the ribosome tunnel and assembly mechanisms driving the formation of the small ribosomal subunit. |
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Authors:
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Joanna Trylska |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Quarterly reviews of biophysics Volume: 42 ISSN: 1469-8994 ISO Abbreviation: Q. Rev. Biophys. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-07-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0144032 Medline TA: Q Rev Biophys Country: England |
Other Details:
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Languages: eng Pagination: 301-16 Citation Subset: IM |
Affiliation:
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Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland. joanna@icm.edu.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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pharmacology Bacteria / chemistry*, drug effects, ultrastructure* Computer Simulation* Models, Biological Models, Molecular Motion Ribosomes* / chemistry, drug effects, physiology, ultrastructure Static Electricity |
| Grant Support | |
ID/Acronym/Agency:
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R03 TW07318/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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