| Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells. | |
| | |
MedLine Citation:
|
PMID: 11162914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the absence of telomerase or other mechanisms to maintain their length, telomeres in human cells shorten at each round of cell division. This has been suggested to ultimately cause cell cycle exit when a critical telomere length is reached, leading to replicative senescence of the cell. At present, it is not clear whether the division potential of human cells is limited by the overall shortening of telomeres at all chromosomes or the shortening of specific telomeres on certain particular chromosomes. By computer simulations, my previous work has suggested that if the telomere theory is correct, the shortening of only a few, most likely two, telomeres might be preferentially involved in restricting the division of human cells. In this work, the length dynamics of individual telomeres in simulated cell clones were examined over their life span. It is shown that if the shortening of only two telomeres is responsible for restricting the proliferation of a cell, these two specific telomeres will shorten at different rates and have different length distributions from those of the rest telomeres. The unique pattern of length dynamics associated with the proliferation-restricting telomeres (PRT) provides a possibility of experimentally identifying these particular telomeres in human cells. |
| | |
Authors:
|
Z Tan |
Related Documents
:
|
12739004 - Absence of hamtert gene expression is associated with promoter hypermethylation in immo... 1722014 - Protein markers for cellular mortality and immortality. 2779554 - Reversible cellular senescence: implications for immortalization of normal human diploi... 12470834 - Assays of proteasome activity in relation to aging. 20623634 - Ozarelix, a fourth generation gnrh antagonist, induces apoptosis in hormone refractory ... 20816884 - Xanthine oxidase-derived reactive oxygen species mediate 4-oxo-2-nonenal-induced hepato... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental gerontology Volume: 36 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2001 Jan |
Date Detail:
|
Created Date: 2001-02-22 Completed Date: 2001-04-12 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
|
Languages: eng Pagination: 89-97 Citation Subset: IM |
Affiliation:
|
College of Life Sciences, Wuhan University, 430072, Wuhan, People's Republic of China. tanclswu@public.wh.hb.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Aging
/
physiology Cell Division / physiology Cell Physiological Phenomena* Cells / cytology* Computer Simulation* Humans Models, Biological* Telomere / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Estimation of replicative senescence via a population dynamics model of cells in culture.
Next Document: Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth...