| Simulated neonatal exposure to DEHP and MEHP from PVC enteral nutrition products. | |
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MedLine Citation:
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PMID: 18063492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The leaching of di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) from medical products made of polyvinyl-chloride (PVC) to enteral nutrition (EN) for neonatal patients was determined in a simulated study. The study simulated a typical case of EN administration to a neonatal patient (body weight, 3 kg) in a neonatal care unit (temperature, 25 degrees C); the medical products used were an irrigator and catheter containing DEHP (9.1-31.8%, w/w) as a plasticizer. The worst-case daily exposures of the neonatal patient to DEHP and MEHP by the administration of EN were estimated to be 148 and 3.72 microg/(kg day), respectively, as assessed from the levels of these compounds leaching from the medical products to the EN. The use of DEHP-free medical products reduced the exposure of DEHP and MEHP to the minimum levels contained in the EN at preparation. A transition to DEHP-free medical products for neonatal patients would be effective in reducing the exposure of neonatal patients to DEHP via EN administration. |
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Authors:
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Satoshi Takatori; You Okamoto; Yoko Kitagawa; Shinjiro Hori; Shun-Ichiro Izumi; Tsunehisa Makino; Hiroyuki Nakazawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-26 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 352 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-26 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Division of Food Chemistry, Osaka Prefectural Institute of Public Health, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. sts-tkt@iph.pref.osaka.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Diethylhexyl Phthalate / adverse effects, analogs & derivatives*, analysis*, chemistry Enteral Nutrition / adverse effects*, instrumentation Equipment Design Food Contamination / prevention & control* Humans Infant Formula / chemistry* Infant, Newborn Intensive Care Units, Neonatal* Plasticizers / adverse effects, analysis* Polyvinyl Chloride / adverse effects, chemistry* Risk Assessment Spectrometry, Mass, Electrospray Ionization Spectrum Analysis, Raman Tandem Mass Spectrometry |
| Chemical | |
Reg. No./Substance:
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0/Plasticizers; 117-81-7/Diethylhexyl Phthalate; 4376-20-9/mono-(2-ethylhexyl)phthalate; 9002-86-2/Polyvinyl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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