| Simulated thin pericardial bioprosthetic valve leaflet deformation under static pressure-only loading conditions: implications for percutaneous valves. | |
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MedLine Citation:
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PMID: 20336372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Percutaneous aortic valve (PAV) replacement is currently being investigated as an endovascular alternative to conventional open-chest valve surgery for patients with severe aortic stenosis. The results of multi-center clinical trials of PAV devices have been encouraging. However, there are serious adverse events associated with this procedure. Furthermore, long-term durability and safety of PAV need to be studied carefully. In this study, we developed a thin pericardial bioprosthetic valve model, which has similar design features of PAV. We utilized this model to investigate PAV deformation under static, pressure-only loading conditions using Finite Element method. Mechanical properties of PAV leaflet were obtained from planar biaxial testing of glutaraldehyde treated thin bovine pericardium (BP) and porcine pericardium (PP), and characterized by the Fung-elastic model. Simulations were performed to examine the effects of tissue thickness and anisotropy on the valve deformation and stress distribution. The results indicated peak stress and strain occurred in the vicinity of commissures. The peak maximum principal stresses (MPS) were reduced with the increase of leaflet tissue thickness, by 36% and 59% from the mean thickness to 0.35 mm for BP and PP, respectively. The PAV with BP leaflet had a lower peak MPS than that with PP leaflet. Moreover, leaflet material orientation had a significant influence on the peak MPS of PAV. |
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Authors:
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Kewei Li; Wei Sun |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-25 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 2690-701 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Biomedical Engineering Program, Tissue Mechanics Laboratory, University of Connecticut, 207 Bronwell Building, Storrs, CT 06269-3139, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anisotropy Aortic Valve / physiology Aortic Valve Stenosis / pathology, physiopathology Cattle Clinical Trials as Topic Drug Administration Routes Heart Valve Prosthesis* Humans Multicenter Studies as Topic Pericardium / surgery* Pressure Swine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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