| Simplified "ATP test" for noninvasive diagnosis of dual AV nodal physiology and assessment of results of slow pathway ablation in patients with AV nodal reentrant tachycardia. | |
| | |
MedLine Citation:
|
PMID: 10749348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: We recently reported that administration of adenosine triphosphate (ATP) during sinus rhythm identifies dual AV nodal physiology (DAVNP) in 76% of patients with inducible sustained AV nodal reentrant tachycardia (AVNRT) at electrophysiologic (EP) study. In that report, however, the ATP test was considered positive for DAVNP only when the results were reproducible at a given dose of ATP. The aim of the present study was to assess the value of a simplified ATP test for noninvasive diagnosis of DAVNP and abolition or modification of the slow pathway (SP) after radiofrequency ablation (RFA) in patients with inducible sustained AVNRT. METHODS AND RESULTS: The value of a single dose of ATP was studied in 105 patients with inducible sustained AVNRT and in 31 control patients before placement of EP catheters in the cardiac chambers. ATP (10 to 60 mg, in 10-mg increments) was injected during sinus rhythm until ECG signs of DAVNP (> or = 50 msec increase or decrease in PR interval in two consecutive beats, or occurrence of > or = 1 AV nodal echo beat) or > or = second-degree AV block was observed. DAVNP was observed in only 1 (3.2%) control patient. The test could be completed in 96 study patients. DAVNP was found by ATP test in 72 (75%) patients, whereas it was diagnosed by EP criteria in 82 (85%) patients. DAVNP by ATP test disappeared in 27 (96%) of 28 patients who underwent SP abolition and in 18 (60%) of 30 patients who underwent SP modification. In the 12 patients with persistent DAVNP determined by ATP test after SP modification, the number of beats conducted over the SP was significantly reduced (from 6.3+/-3.3 to 2.5+/-2.2 beats; P = 0.002). CONCLUSION: A single administration of ATP during sinus rhythm (at a given dose) enables noninvasive diagnosis of DAVNP in a high percentage of patients with inducible AVNRT and reliably confirms the results of RFA of the SP. |
| | |
Authors:
|
B Belhassen; R Fish; M Eldar; A Glick; M Glikson; S Viskin |
Related Documents
:
|
20801568 - Association of low serum fetuin a levels with poor arteriovenous access patency in pati... 19542538 - Intra-his bundle block in second-degree mobitz i atrioventricular block with right bund... 21459688 - Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice. 1692128 - Mechanism of double ventricular response to a single atrial extrastimulus in patients w... 16961728 - Successful percutaneous coronary intervention using bivalirudin in a patient with chron... 8620778 - Perianal crohn's disease--is it all bad news? |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
|
Title: Journal of cardiovascular electrophysiology Volume: 11 ISSN: 1045-3873 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-05-19 Completed Date: 2000-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 255-61 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Tel-Aviv Sourasky Medical Center, Israel. bblhass@tasmc.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
administration & dosage,
diagnostic use* Atrioventricular Node / abnormalities*, physiopathology, surgery Catheter Ablation* Electrocardiography Female Heart Rate / drug effects, physiology* Humans Injections, Intravenous Male Middle Aged Prospective Studies Reproducibility of Results Tachycardia, Atrioventricular Nodal Reentry / diagnosis*, etiology, physiopathology, surgery Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patterns of accelerated junctional rhythm during slow pathway catheter ablation for atrioventricular...
Next Document: Preferential depression of conduction around a pivot point in rabbit ventricular myocardium by potas...