Document Detail

Simplified experimental cerebral aneurysm model in rats: comprehensive evaluation of induced aneurysms and arterial changes in the circle of Willis.
MedLine Citation:
PMID:  19747458     Owner:  NLM     Status:  MEDLINE    
Establishing a simple and comprehensive experimental model is one of the most important issues in the study of cerebral aneurysms. Previous models in the rat required two stage surgeries and observations were limited to a few branching sites. The present study aimed to introduce a simplified model in rats and to provide a comprehensive evaluation of induced arterial changes in the circle of Willis. Sprague-Dawley rats underwent ligation of the right common carotid artery, and posterior and inferior (group 2, n=9) or only posterior (group 3, n=12) branches of the bilateral renal arteries, and bilateral oophorectomy. Dahl salt-sensitive rats underwent only carotid ligation and bilateral oophorectomy (group 5, n=11). All surgical procedures were completed in one procedure instead of two in the original method. Salt loading was started after the surgery. Five rats of each strain without treatment served as controls (groups 1 and 4, respectively). Three months later, vascular corrosion casts of the cerebral arteries were examined by scanning electron microscopy. Experimental rats in groups 2, 3, and 5 developed 43 aneurysmal lesions at branching sites. Forty-eight arterial changes including dilatation, tortuosity, and fusiform or lateral wall aneurysms were observed at non-branching sites. Group 3 appeared to be superior to the other groups for experimental studies. The frequency and degree of the induced lesions were comparable with previous studies even after the surgical simplification. The present model may be more practical for the study of experimental cerebral aneurysms.
Hany Eldawoody; Hiroaki Shimizu; Naoto Kimura; Atsushi Saito; Toshio Nakayama; Akira Takahashi; Teiji Tominaga
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Publication Detail:
Type:  Journal Article     Date:  2009-09-09
Journal Detail:
Title:  Brain research     Volume:  1300     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-27     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Brain / pathology,  surgery*
Cerebrovascular Circulation
Chi-Square Distribution
Circle of Willis / pathology,  surgery*
Disease Models, Animal*
Microscopy, Electron, Scanning
Neurosurgical Procedures
Rats, Inbred Dahl
Rats, Sprague-Dawley
Subarachnoid Hemorrhage / pathology,  surgery*

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