| Simplified structure of a new model to describe urinary excretion of plutonium after systemic, liver or pulmonary contamination of rats associated with Ca-DTPA treatments. | |
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MedLine Citation:
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PMID: 19580474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study validates, by targeted experiments, several modeling hypotheses for interpretation of urinary excretion of plutonium after Ca-DTPA treatments. Different formulations and doses of Ca-DTPA were administered to rats before or after systemic, liver or lung contamination with various chemical forms of plutonium. The biokinetics of plutonium was also characterized after i.v. injection of Pu-DTPA. Once formed, Pu-DTPA complexes are stable in most biological environments. Pu-DTPA present in circulating fluids is rapidly excreted in the urine, but 2-3% is retained, mainly in soft tissues, and is then excreted slowly in the urine after transfer to blood. Potentially, all intracellular monoatomic forms of plutonium could be decorporated after DTPA internalization involving slow urinary excretion of Pu-DTPA with half-lives varying from 2.5 to 6 days as a function of tissue retention. The ratio of fast to slow urinary excretion of Pu-DTPA depends on both plutonium contamination and Ca-DTPA treatment. Fast urinary excretion of Pu-DTPA corresponds to extracellular decorporation that occurs beyond a threshold of the free DTPA concentration in circulating fluids. Slow excretion corresponds mostly to intracellular decorporation and depends on the amount of intracellular DTPA. From these results, the structure of a simplified model is proposed for interpretation of data obtained with Ca-DTPA treatments after systemic, wound or pulmonary contamination by plutonium. |
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Authors:
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P Fritsch; A L Sérandour; O Grémy; G Phan; N Tsapis; M C Abram; D Renault; E Fattal; H Benech; J R Deverre; J L Poncy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiation research Volume: 171 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-07 Completed Date: 2009-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 674-86 Citation Subset: IM; S |
Affiliation:
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CEA/DSV/iRCM/SREIT/LRT, 91680 Bruyères le Châtel, France. paul.fritsch@cea.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Autoradiography Bone and Bones / chemistry, drug effects, radiation effects Citric Acid / toxicity Feces / chemistry Half-Life Kinetics Liver / chemistry, drug effects, radiation effects Lung / chemistry, drug effects, radiation effects Male Models, Biological* Pentetic Acid / administration & dosage, chemistry, therapeutic use* Plutonium / analysis, chemistry, toxicity*, urine* Radiation Injuries, Experimental / prevention & control*, urine Radiation-Protective Agents / administration & dosage, therapeutic use* Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Radiation-Protective Agents; 12059-95-9/plutonium dioxide; 67-43-6/Pentetic Acid; 7261-07-6/plutonium citrate; 7440-07-5/Plutonium; 77-92-9/Citric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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