| A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sj?gren's Syndrome International Registry. | |
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MedLine Citation:
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PMID: 20035924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe, apply, and test a new ocular grading system for assessing keratoconjunctivitis sicca (KCS) using lissamine green and fluorescein. DESIGN: Prospective, observational, multicenter cohort study. METHODS: The National Institutes of Health-funded Sj?gren's Syndrome International Registry (called Sj?gren's International Collaborative Clinical Alliance [SICCA]) is developing standardized classification criteria for Sj?gren syndrome (SS) and is creating a biospecimen bank for future research. Eight SICCA ophthalmologists developed a new quantitative ocular grading system (SICCA ocular staining score [OSS]), and we analyzed OSS distribution among the SICCA cohort and its association with other phenotypic characteristics of SS. The SICCA cohort includes participants ranging from possibly early SS to advanced disease. Procedures include sequenced unanesthetized Schirmer test, tear break-up time, ocular surface staining, and external eye examination at the slit lamp. Using statistical analyses and proportional Venn diagrams, we examined interrelationships between abnormal OSS (>or=3) and other characteristics of SS (labial salivary gland [LSG] biopsy with focal lymphocytic sialadenitis and focus score >1 positive anti-SS A antibodies, anti-SS B antibodies, or both). RESULTS: Among 1208 participants, we found strong associations between abnormal OSS, positive serologic results, and positive LSG focus scores (P < .0001). Analysis of the overlapping relationships of these 3 measures defined a large group of participants who had KCS without other components of SS, representing a clinical entity distinct from the KCS associated with SS. CONCLUSIONS: This new method for assessing KCS will become the means for diagnosing the ocular component of SS in future classification criteria. We find 2 forms of KCS whose causes may differ. |
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Authors:
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John P Whitcher; Caroline H Shiboski; Stephen C Shiboski; Ana Maria Heidenreich; Kazuko Kitagawa; Shunhua Zhang; Steffen Hamann; Genevieve Larkin; Nancy A McNamara; John S Greenspan; Troy E Daniels; |
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Publication Detail:
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Type: Journal Article; Multicenter Study Date: 2009-12-29 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 149 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 405-15 Citation Subset: AIM; IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143-0422, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Coloring Agents / diagnostic use* Female Fluorescein / diagnostic use Fluorescent Dyes / diagnostic use* Humans International Classification of Diseases Keratoconjunctivitis Sicca / classification, diagnosis* Lissamine Green Dyes / diagnostic use Male Middle Aged Prospective Studies Registries Sjogren's Syndrome / classification, diagnosis* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Fluorescent Dyes; 0/Lissamine Green Dyes; 2321-07-5/Fluorescein |
| Investigator | |
Investigator/Affiliation:
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K Sack / ; D Lee / ; E Strauss / ; M Chan / ; A Wu / ; D Greenspan / ; D Cox / ; R Jordan / ; Y DeSouza / ; D Drury / ; L Scott / ; H Lanfranchi / ; C Vollenweider / ; I Adler / ; A Smith / ; M Gandolfo / ; P M Bisio / ; A Keszler / ; A Chirife / ; S Daverio / ; V Kambo / ; Y Dong / ; Y Zhao / ; M Li / ; W Zhang / ; W Zheng / ; Y Jiang / ; D Xu / ; J Su / ; J Zhao / ; D Du / ; J Xiao / ; H Wang / ; Q Wu / ; C Zhang / ; W Meng / ; M Schi?dt / ; S Johansen / ; P Helin / ; H Holm / ; P Ibsen / ; A M Manniche / ; S P Kreutzmann / ; H Umehara / ; Y Masaki / ; M Tanaka / ; T Sawaki / ; K Hagiwara / ; T Nojima / ; N Kurose / ; M Hondo / ; T Kawanami / ; K Fujimoto / ; S Challacombe / ; P Shirlaw / ; B Jacobs / ; F Barone / ; E Odell / ; P Morgan / ; L Fernandes-Naglik / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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