| Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model. | |
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MedLine Citation:
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PMID: 21441533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: Nine pigs had dynamic PET scans after repeated injections of flurpiridaz F 18 at rest and combined adenosine and dobutamine stress. flurpiridaz F 18 PET with a 3-compartment model and coinjected radioactive microspheres were used to delineate MBF. These quantitative measurements were compared with myocardial retention (%/min) and SUV of flurpiridaz F 18 after summing data over 5-10, 5-12, 5-15, 10-15, and 10-20 min after tracer injection. RESULTS: MBF ranged from 0.5 to 2.8 mL/min/g. There was a good correlation between both flurpiridaz F 18 retention and SUVs from 5 to 12 min after injection and MBF measured using 3-compartment model- or microsphere-derived MBF (r = 0.73, P < 0.05, and r = 0.68, P < 0.05, respectively, for retention; r = 0.88, P < 0.001, and r = 0.92, P < 0.001, respectively, for SUV). At later time points, retention and SUV underestimated stress microsphere flow (at 10-20 min: r = 0.41, P = not significant, and r = 0.46, P = not significant, respectively, for retention; r = 0.41, P = not significant, and r = 0.65, P < 0.05, respectively, for SUV). When measured 5-12 min after injection, there was a close agreement between MFR measured with either flurpiridaz F 18 retention or SUV and MFR measured using microspheres (mean difference, -0.08 ± 0.36 and -0.18 ± 0.25, respectively). CONCLUSION: Myocardial retention and SUVs of the (18)F-labeled flow tracer flurpiridaz F 18 accurately reflect the MFR. These simplified analysis methods may facilitate the combination of quantitative assessment of perfusion reserve and rapid clinical imaging protocols. |
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Authors:
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Hossam M Sherif; Stephan G Nekolla; Antti Saraste; Sybille Reder; Ming Yu; Simon Robinson; Markus Schwaiger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 52 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: 2011-05-31 Revised Date: 2011-12-08 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 617-24 Citation Subset: IM |
Affiliation:
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Nuklearmedizinische Klinik und Poliklinik der Technischen Universität München, Munich, Germany. hossam_sherif_66@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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diagnostic use Animals Cardiotonic Agents / diagnostic use Coronary Circulation / physiology* Dobutamine / diagnostic use Gated Blood-Pool Imaging Heart / radionuclide imaging* Image Processing, Computer-Assisted Microspheres Myocardium / metabolism Positron-Emission Tomography Pyridazines / diagnostic use*, pharmacokinetics Radiopharmaceuticals / diagnostic use*, pharmacokinetics Regression Analysis Reproducibility of Results Scintillation Counting Swine |
| Chemical | |
Reg. No./Substance:
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0/BMS 747158-02; 0/Cardiotonic Agents; 0/Pyridazines; 0/Radiopharmaceuticals; 34368-04-2/Dobutamine; 58-61-7/Adenosine |
| Comments/Corrections | |
Comment In:
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J Nucl Med. 2011 Nov;52(11):1835; author reply 1835-6
[PMID:
22045710
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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