| Simplified pulse reactor for real-time long-term in vitro testing of biological heart valves. | |
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MedLine Citation:
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PMID: 20204701 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term function of biological heart valve prostheses (BHV) is limited by structural deterioration leading to failure with associated arterial hypertension. The objective of this work was development of an easy to handle real-time pulse reactor for evaluation of biological and tissue engineered heart valves under different pressures and long-term conditions. The pulse reactor was made of medical grade materials for placement in a 37 degrees C incubator. Heart valves were mounted in a housing disc moving horizontally in culture medium within a cylindrical culture reservoir. The microprocessor-controlled system was driven by pressure resulting in a cardiac-like cycle enabling competent opening and closing of the leaflets with adjustable pulse rates and pressures between 0.25 to 2 Hz and up to 180/80 mmHg, respectively. A custom-made imaging system with an integrated high-speed camera and image processing software allow calculation of effective orifice areas during cardiac cycle. This simple pulse reactor design allows reproducible generation of patient-like pressure conditions and data collection during long-term experiments. |
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Authors:
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Martina Schleicher; G?nther Sammler; Michael Schmauder; Olaf Fritze; Agnes J Huber; Katja Schenke-Layland; G?nter Ditze; Ulrich A Stock |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-05 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 38 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 1919-27 Citation Subset: IM |
Affiliation:
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Department of Thoracic, Cardiac and Vascular Surgery, University Hospital T?bingen, 72076 T?bingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Rate Heart Valve Prosthesis / standards* Heart Valves / physiopathology Humans Microcomputers Physical Processes Pressure Time |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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