Document Detail

Simple method for the analysis of tenoxicam in human plasma using high-performance liquid chromatography.
MedLine Citation:
PMID:  7795823     Owner:  NLM     Status:  MEDLINE    
A simple, rapid and cost-effective method for the determination of tenoxicam in human plasma is described, using ketorolac as the internal standard. The extraction procedure utilised 5% zinc sulphate and methanol. A nucleosil C18 column and 35:65 acetonitrile-water phosphate buffered mobile phase (pH 2.8) were used, with ultraviolet detection at 355 nm. The assay was linear in the range 40 ng/ml-10 micrograms/ml, with recovery of extraction ranging from 87 to 102%. The intra- and inter-assay reproducibility had coefficients of variation of 3.9-7.7 and 1.6% respectively. The limit of detection for this method was 40 ng/ml.
J L Mason; G J Hobbs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography. B, Biomedical applications     Volume:  665     ISSN:  1572-6495     ISO Abbreviation:  J. Chromatogr. B, Biomed. Appl.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2007-10-16    
Medline Journal Info:
Nlm Unique ID:  9421796     Medline TA:  J Chromatogr B Biomed Appl     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  410-5     Citation Subset:  IM    
University Department of Anaesthesia, Queens Medical Centre, Nottingham, UK.
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MeSH Terms
Chromatography, High Pressure Liquid / methods*,  statistics & numerical data
Drug Stability
Hydrogen-Ion Concentration
Piroxicam / analogs & derivatives*,  blood,  pharmacokinetics
Reproducibility of Results
Zinc Compounds
Zinc Sulfate
Reg. No./Substance:
0/Sulfates; 0/Zinc Compounds; 36322-90-4/Piroxicam; 59804-37-4/tenoxicam; 67-56-1/Methanol; 7733-02-0/Zinc Sulfate
Erratum In:
J Chromatogr B Biomed Appl 1995 May 19;667(2):361

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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