Document Detail


Simple isolated perfused artery preparation: vasoconstrictor evaluation.
MedLine Citation:
PMID:  1133697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small mesenteric arteries free of all extraarterial tissues were obtained from anesthetized dogs and perfused in vitro with Krebs solution. Vasoconstrictor responses of these arteries to intraarterial levarterenol and epinephrine were dose related and equivalent to those of arteries surrounded by fat and other tissues. Responsiveness was stable for at least 60 min. This simple preparation is useful for the study of vasoconstrictor phenomena uncomplicated arterial tissue.
Authors:
C M Davis; T F Burks
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  64     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-08-26     Completed Date:  1975-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheterization
Dogs
Dose-Response Relationship, Drug
Epinephrine / pharmacology
Female
Injections, Intra-Arterial
Intestine, Small / blood supply
Male
Mesenteric Arteries / drug effects*
Norepinephrine / pharmacology
Perfusion / methods
Regional Blood Flow / drug effects
Vasoconstrictor Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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