| Simple isolated perfused artery preparation: vasoconstrictor evaluation. | |
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MedLine Citation:
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PMID: 1133697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small mesenteric arteries free of all extraarterial tissues were obtained from anesthetized dogs and perfused in vitro with Krebs solution. Vasoconstrictor responses of these arteries to intraarterial levarterenol and epinephrine were dose related and equivalent to those of arteries surrounded by fat and other tissues. Responsiveness was stable for at least 60 min. This simple preparation is useful for the study of vasoconstrictor phenomena uncomplicated arterial tissue. |
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Authors:
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C M Davis; T F Burks |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 64 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-08-26 Completed Date: 1975-08-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 170-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheterization Dogs Dose-Response Relationship, Drug Epinephrine / pharmacology Female Injections, Intra-Arterial Intestine, Small / blood supply Male Mesenteric Arteries / drug effects* Norepinephrine / pharmacology Perfusion / methods Regional Blood Flow / drug effects Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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