Document Detail

Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer.
MedLine Citation:
PMID:  17935328     Owner:  NLM     Status:  MEDLINE    
We have developed a simple and effective molecular imprinting technique to target compounds with flexible structure. Domoic acid (DA), an amnesic shellfish poison, was used as the target compound while many acidic compounds (mono-, di-, and tricarboxylic acids) were used as template molecules for molecularly imprinted polymers (MIPs). Evaluation of selective recognition abilities using liquid chromatography revealed that the highest selective recognition ability for DA was found when pentane-1,3,5-tricarboxylic acid (1,3,5-PeTA) was used as the template. Computer modeling studies of the DA structure suggested that the observed selective recognition depended on the structural changes in DA at the recognition site of the MIPs as well as spatial distance between the COOH groups in DA and 1,3,5-PeTA. Using the 1,3,5-PeTA-MIP, we could easily purify DA from blue mussel extracts by solid-phase extraction.
Koji Nemoto; Takuya Kubo; Makoto Nomachi; Tomoharu Sano; Takatoshi Matsumoto; Ken Hosoya; Tetsutaro Hattori; Kunimitsu Kaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-13
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  129     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-31     Completed Date:  2008-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13626-32     Citation Subset:  IM    
Graduate School of Environmental Studies, Tohoku University, Aoba 6-6-20, Aramaki, Aoba-ku, Sendai, Japan.
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MeSH Terms
Chromatography, Liquid / methods
Hydrogen-Ion Concentration
Kainic Acid / analogs & derivatives*,  chemistry
Models, Chemical
Molecular Conformation
Molecular Imprinting
Pentanes / chemistry*
Polymers / chemistry*
Sensitivity and Specificity
Tricarboxylic Acids / chemistry*
Reg. No./Substance:
0/Pentanes; 0/Polymers; 0/Tricarboxylic Acids; 109-66-0/pentane; 14277-97-5/domoic acid; 487-79-6/Kainic Acid

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