| Simple and effective 3D recognition of domoic acid using a molecularly imprinted polymer. | |
| | |
MedLine Citation:
|
PMID: 17935328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have developed a simple and effective molecular imprinting technique to target compounds with flexible structure. Domoic acid (DA), an amnesic shellfish poison, was used as the target compound while many acidic compounds (mono-, di-, and tricarboxylic acids) were used as template molecules for molecularly imprinted polymers (MIPs). Evaluation of selective recognition abilities using liquid chromatography revealed that the highest selective recognition ability for DA was found when pentane-1,3,5-tricarboxylic acid (1,3,5-PeTA) was used as the template. Computer modeling studies of the DA structure suggested that the observed selective recognition depended on the structural changes in DA at the recognition site of the MIPs as well as spatial distance between the COOH groups in DA and 1,3,5-PeTA. Using the 1,3,5-PeTA-MIP, we could easily purify DA from blue mussel extracts by solid-phase extraction. |
| | |
Authors:
|
Koji Nemoto; Takuya Kubo; Makoto Nomachi; Tomoharu Sano; Takatoshi Matsumoto; Ken Hosoya; Tetsutaro Hattori; Kunimitsu Kaya |
Related Documents
:
|
2380108 - A54145, a new lipopeptide antibiotic complex: microbial and chemical modification. 23006568 - Biosynthesis of silver nanoparticles using alternanthera sessilis (linn.) extract and t... 17048828 - 13c nmr-based empirical rules to determine the configuration of fatty acid butanolides.... 23183228 - A regional examination of episodic acidification response to reduced acidic deposition ... 14556488 - Determination of immunological activity in vitro of some plant raw materials. 10029138 - Biochemical effects of high intensity constant magnetic fields on worker honey bees. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-13 |
Journal Detail:
|
Title: Journal of the American Chemical Society Volume: 129 ISSN: 0002-7863 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-10-31 Completed Date: 2008-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
|
Languages: eng Pagination: 13626-32 Citation Subset: IM |
Affiliation:
|
Graduate School of Environmental Studies, Tohoku University, Aoba 6-6-20, Aramaki, Aoba-ku, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromatography, Liquid
/
methods Hydrogen-Ion Concentration Kainic Acid / analogs & derivatives*, chemistry Models, Chemical Molecular Conformation Molecular Imprinting Pentanes / chemistry* Polymers / chemistry* Sensitivity and Specificity Tricarboxylic Acids / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Pentanes; 0/Polymers; 0/Tricarboxylic Acids; 109-66-0/pentane; 14277-97-5/domoic acid; 487-79-6/Kainic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extended sugar-assisted glycopeptide ligations: development, scope, and applications.
Next Document: Molecular dynamics simulations of the catalytic pathway of a cysteine protease: a combined QM/MM stu...