Document Detail

Simple closure or vagotomy and pyloroplasty for the treatment of a perforated duodenal ulcer: comparison of results.
MedLine Citation:
PMID:  10867454     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Treatment of the perforated duodenal ulcer continues to be a controversial subject. The purpose of our study was to compare the results of simple closure of perforated duodenal ulcer versus treatment by truncal vagotomy and pyloroplasty. METHODS: We present a prospective and randomized study of 207 patients who underwent surgical treatment due to perforated duodenal ulcer. In 117 patients the surgical treatment was simple closure and postsurgery medical treatment with proton pump inhibitors for 1 month, and in 90 patients vagotomy and pyloroplasty with no additional medical treatment. RESULTS: We applied the Visick scale in order to compare postsurgery results. The postoperative morbidity and mortality rates were the same with both techniques. Statistically, in both cases, no significant differences were found in postsurgery symptomatology. The different rates of recurrent ulcers and the reinterventions due to recurrent ulcers presented no significant statistical values. CONCLUSION: We conclude that simple closure remains the selected treatment in the majority of patients who present with a perforated duodenal ulcer. The operation is a simple and safe procedure.
C Gutiérrez de la Peña; R Márquez; F Fakih; E Domínguez-Adame; J Medina
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Digestive surgery     Volume:  17     ISSN:  0253-4886     ISO Abbreviation:  Dig Surg     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-23     Completed Date:  2000-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501808     Medline TA:  Dig Surg     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Department of Surgery, Jerez de la Frontera University Hospital, Jerez de la Frontera, Spain.
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MeSH Terms
Duodenal Ulcer / complications*
Intestinal Perforation / surgery*
Middle Aged
Postoperative Complications
Prospective Studies
Proton Pumps / antagonists & inhibitors
Pyloric Antrum / surgery
Treatment Outcome
Reg. No./Substance:
0/Proton Pumps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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