Document Detail


Simple area-based measurement for multidetector computed tomography to predict left ventricular size.
MedLine Citation:
PMID:  20204649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Measures of left ventricular (LV) mass and dimensions are independent predictors of morbidity and mortality. We determined whether an axial area-based method by computed tomography (CT) provides an accurate estimate of LV mass and volume.
METHOD: A total of 45 subjects (49% female, 56.0 +/- 12 years) with a wide range of LV geometry underwent contrast-enhanced 64-slice CT. LV mass and volume were derived from 3D data. 2D images were analysed to determine LV area, the direct transverse cardiac diameter (dTCD) and the cardiothoracic ratio (CTR). Furthermore, feasibility was confirmed in 100 Framingham Offspring Cohort subjects.
RESULTS: 2D measures of LV area, dTCD and CTR were 47.3 +/- 8 cm(2), 14.7 +/- 1.5 cm and 0.54 +/- 0.05, respectively. 3D-derived LV volume (end-diastolic) and mass were 148.9 +/- 45 cm(3) and 124.2 +/- 34 g, respectively. Excellent inter- and intra-observer agreement were shown for 2D LV area measurements (both intraclass correlation coefficients (ICC) = 0.99, p < 0.0001) and could be confirmed on non-contrast CT. The measured 2D LV area was highly correlated to LV volume, mass and size (r = 0.68; r = 0.73; r = 0.82; all p < 0.0001, respectively). On the other hand, CTR was not correlated to LV volume, mass, size or 2D LV area (all p > 0.27).
CONCLUSION: Compared with traditionally used CTR, LV size can be accurately predicted based on a simple and highly reproducible axial LV area-based measurement.
Authors:
Christopher L Schlett; Dylan C Kwait; Amir A Mahabadi; Fabian Bamberg; Christopher J O'Donnell; Caroline S Fox; Udo Hoffmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-04
Journal Detail:
Title:  European radiology     Volume:  20     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-09-21     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1590-6     Citation Subset:  IM    
Affiliation:
Cardiac MR PET CT Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Female
Heart Ventricles / anatomy & histology*,  radiography*
Humans
Lung / radiography*
Lung Volume Measurements
Male
Middle Aged
Organ Size
Predictive Value of Tests
Reproducibility of Results
Tomography, X-Ray Computed*
Ventricular Function, Left*
Grant Support
ID/Acronym/Agency:
K24 HL113128/HL/NHLBI NIH HHS; N01 HC025195/HC/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 HL080053/HL/NHLBI NIH HHS; R01 HL080053/HL/NHLBI NIH HHS; R01 HL080053-03/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Eur Radiol. 2010 Jul;20(7):1597-8   [PMID:  20204648 ]

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