Document Detail


Simple alternatives using a single centrifugal pump for biventricular assistance in cardiogenic shock.
MedLine Citation:
PMID:  2345378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The application of pumps and other mechanical and physiologic aids for improving circulation and heart recovery must be based on physiologic requirements. The needs of circulation and cardiac recovery are different and depend on competence of the right ventricle as well as the left ventricle and the pattern of cannulation and decompression. Our studies of various bypass techniques and drugs in a standardized severe cardiogenic shock model lead us to believe that biventricular decompression can be accomplished with a single centrifugal pump without an oxygenator. Cardiogenic shock and severe biventricular failure was best treated by LV + RA bypass, based on survival, hemodynamics and metabolism. LA + RA bypass was the next best. LA bypass, LV bypass, substrates (cysteine and ribose) and nitroprusside were intermediate. Circulatory support is not enough unless appropriate cardiac decompression ensures myocardial recovery.
Authors:
A A Lefemine; J Dunbar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomaterials applications     Volume:  4     ISSN:  0885-3282     ISO Abbreviation:  J Biomater Appl     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8813912     Medline TA:  J Biomater Appl     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  333-61     Citation Subset:  IM    
Affiliation:
VA Central Office, Washington, DC 20420.
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MeSH Terms
Descriptor/Qualifier:
Equipment Design
Heart-Assist Devices*
Hemodynamics
Humans
Shock, Cardiogenic / mortality,  physiopathology,  therapy*
Survival Analysis

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