| A simple method for principal strata effects when the outcome has been truncated due to death. | |
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MedLine Citation:
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PMID: 21354986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In randomized trials with follow-up, outcomes such as quality of life may be undefined for individuals who die before the follow-up is complete. In such settings, restricting analysis to those who survive can give rise to biased outcome comparisons. An alternative approach is to consider the "principal strata effect" or "survivor average causal effect" (SACE), defined as the effect of treatment on the outcome among the subpopulation that would have survived under either treatment arm. The authors describe a very simple technique that can be used to assess the SACE. They give both a sensitivity analysis technique and conditions under which a crude comparison provides a conservative estimate of the SACE. The method is illustrated using data from the ARDSnet (Acute Respiratory Distress Syndrome Network) clinical trial comparing low-volume ventilation and traditional ventilation methods for individuals with acute respiratory distress syndrome. |
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Authors:
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Yasutaka Chiba; Tyler J VanderWeele |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-02-25 |
Journal Detail:
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Title: American journal of epidemiology Volume: 173 ISSN: 1476-6256 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-05 Completed Date: 2011-06-28 Revised Date: 2012-04-02 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 745-51 Citation Subset: IM |
Affiliation:
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Department of Environmental Medicine and Behavioral Science, Kinki University School of Medicine, 377-2 Ohno-higashi, Osakasayama, Osaka, Japan. chibay@med.kindai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Causality* Epidemiologic Methods Humans Models, Statistical* Quality of Life Randomized Controlled Trials as Topic Respiration, Artificial / methods* Respiratory Distress Syndrome, Adult / mortality*, therapy* Survival Analysis Survivors Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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HD060696/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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