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Simple Cystatin C Formula Compared to Serum Creatinine-Based Formulas for Estimation of Glomerular Filtration Rate in Patients with Mildly to Moderately Impaired Kidney Function.
MedLine Citation:
PMID:  23095576     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Serum cystatin C (SCC)-based formulas and the newer creatinine formula (the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)) were proposed as improved glomerular filtration rate (GFR) markers. The aim of our study was to compare serum creatinine (SCr)-based and SCC-based equations against (51)Cr-EDTA clearance in patients with mildly to moderately impaired kidney function. Methods: 255 adult Caucasian patients with chronic kidney disease (GFR 89-30 ml/min/1.73 m(2)) were enrolled. In each patient, (51)Cr-EDTA clearance, SCr and SCC were determined. GFR was calculated using the Cockcroft-Gault (C&G), Modification of Diet in Renal Disease (MDRD), CKD-EPI formulas and simple cystatin C formula (SCCF) (100/SCC). Results: The receiver-operating characteristic curve analysis (cut-off for GFR 60 ml/min/1.73 m(2)) showed that the SCCF had a higher diagnostic accuracy than C&G but not than MDRD or CKD-EPI formulas. The Bland-Altman analysis for the same cut-off value showed that creatinine formulas underestimated and SCCF overestimated the measured GFR. Analysis of ability to correctly predict a patient's GFR <60 or >60 ml/min/1.73 m(2) showed the higher ability for the SCCF compared to all creatinine-based formulas. Conclusion: Our results indicate that the SCCF is a reliable marker of GFR and comparable to creatinine formulas including the CKD-EPI formula.
Authors:
Sebastjan Bevc; Radovan Hojs; Robert Ekart; Maksimiljan Gorenjak; Ludvik Puklavec
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-19
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  35     ISSN:  1423-0143     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  649-654     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Nephrology, Clinic of Internal Medicine, Maribor, Slovenia.
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