Document Detail

A Simple Computational Cell: Coupling Boolean Gene and Protein Networks.
MedLine Citation:
PMID:  22356156     Owner:  NLM     Status:  Publisher    
Abstract This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.
Larry Bull
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  Artificial life     Volume:  -     ISSN:  1064-5462     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433814     Medline TA:  Artif Life     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of the West of England.
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