Document Detail

Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors.
MedLine Citation:
PMID:  11083234     Owner:  NLM     Status:  MEDLINE    
The single photon emission computed tomography (SPECT) radiotracer [123I]iomazenil is used to assess benzodiazepine receptor binding parameters. These measurements are relative indices of benzodiazepine receptor concentration (B'max). To evaluate the ability of such indices in accurately accessing the B'max the authors compared them with absolute values of B'max, measured using positron emission tomography (PET). The authors performed SPECT, PET, and magnetic resonance imaging (MRI) studies on a group composed of seven subjects. For SPECT studies, the authors administered a single injection of [123I]iomazenil and estimated the total and specific distribution volumes (DV(T SPECT), DV(S SPECT)) and the binding potential (BP) using unconstrained (BP(SPECT)) and constrained (BP(C SPECT)) compartmental models. For PET studies, the authors used a multiinjection approach with [11C]flumazenil and unlabeled flumazenil to estimate absolute values of receptor concentration, B'max, and some other binding parameters. The authors studied the correlation of different binding parameters with B'max. To study the robustness of the binding parameter measurements at the pixel level, the authors applied a wavelet-based filter to improve signal-to-noise ratio of time-concentration curves, and the calculated kinetic parameters were used to build up parametric images. For PET data, the B'max and the DV(PET) were highly correlated (r = 0.988). This confirms that it is possible to use the DV(PET) to access benzodiazepine receptor density. For SPECT data, the correlation between DV(SPECT) estimated using a two- and three-compartment model was also high (r = 0.999). The DV(T SPECT) and BP(C SPECT) parameters estimated with a constrained three-compartment model or the DV(T''SPECT) parameter estimated with a two-compartment model were also highly correlated to the B'max parameter estimated with PET. Finally, the robustness of the binding parameters allowed the authors to build pixel-by-pixel parametric images using SPECT data.
P Millet; C Graf; A Buck; B Walder; G Westera; C Broggini; M Arigoni; D Slosman; C Bouras; V Ibáñez
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  20     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-17     Completed Date:  2000-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1587-603     Citation Subset:  IM    
Department of Psychiatry, University Hospital of Geneva, Switzerland.
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MeSH Terms
Brain Chemistry*
Carbon Radioisotopes / diagnostic use
Flumazenil / analogs & derivatives*,  metabolism,  pharmacology
GABA Modulators / metabolism,  pharmacology
Iodine Radioisotopes / diagnostic use
Models, Biological
Receptors, GABA-A / analysis*,  metabolism
Reproducibility of Results
Tomography, Emission-Computed / standards*
Tomography, Emission-Computed, Single-Photon / standards*
Reg. No./Substance:
0/Carbon Radioisotopes; 0/GABA Modulators; 0/Iodine Radioisotopes; 0/Receptors, GABA-A; 127396-36-5/iomazenil; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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