Document Detail


Similarity of acetaldehyde and sulfhydryl reagent actions on the perfused guinea pig heart.
MedLine Citation:
PMID:  1108126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acetaldehyde (1 mM) and two known sulfhydryl reagents, diamide (0.25 mM) and cystamine (0.5 mM), on the perfused guinea pig heart were compared and were found to be markedly similar. All compounds increased heart rate and coronary flow. Dichloroisoproterenol blocked the increase in heart rate but not the increase in coronary flow. It is concluded that acetaldehyde may produce its effects by reaction with cellular thiols.
Authors:
M H Nguyen; L Gailis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Recent advances in studies on cardiac structure and metabolism     Volume:  10     ISSN:  0363-5872     ISO Abbreviation:  Recent Adv Stud Cardiac Struct Metab     Publication Date:  1975  
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0325677     Medline TA:  Recent Adv Stud Cardiac Struct Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetaldehyde / pharmacology*
Animals
Azo Compounds / pharmacology
Coronary Circulation / drug effects
Cystamine / pharmacology
Formamides / pharmacology
Guinea Pigs
Heart / drug effects*
Heart Rate / drug effects
Male
Perfusion
Sulfhydryl Reagents / pharmacology*
Chemical
Reg. No./Substance:
0/Azo Compounds; 0/Formamides; 0/Sulfhydryl Reagents; 51-85-4/Cystamine; 75-07-0/Acetaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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