| Similarities and differences in arterial responses to hypercapnia and visual stimulation. | |
| | |
MedLine Citation:
|
PMID: 20700127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Despite the different origins of cerebrovascular activity induced by neurogenic and nonneurogenic conditions, a standard assumption in functional studies is that the consequence on the vascular system will be mechanically similar. Using a recently developed arterial spin labeling method, we examined arterial blood volume, arterial-microvascular transit time, and cerebral blood flow (CBF) in the gray matter and in areas with large arterial vessels under hypercapnia, visual stimulation, and a combination of the two. Spatial heterogeneity in arterial reactivity was observed between conditions. During hypercapnia, large arterial volume changes contributed to CBF increase and further downstream, there were reductions in the gray matter transit time. These changes were not significant during visual stimulation, and during the combined condition they were moderated. These findings suggest distinct vascular mechanisms for large and small arterial segments that may be condition specific. However, the power relationships between gray matter arterial blood volume and CBF in hypercapnia (α=0.69±0.24) and visual stimulation (α=0.68±0.20) were similar. Assuming consistent capillary and venous volume responses across these conditions, these results offer support for a consistent total CBV-flow relationship typically assumed in blood oxygen-level dependent calibration techniques. |
| | |
Authors:
|
Yi-Ching Lynn Ho; Esben Thade Petersen; Ivan Zimine; Xavier Golay |
Related Documents
:
|
19219847 - The effect of daily caffeine use on cerebral blood flow: how much caffeine can we toler... 469577 - Relation of cerebral blood flow to neurological status and outcome in head-injured pati... 1336887 - Sequential change of heterogeneous cerebral blood blow patterns after diffuse brain isc... 7511347 - Hypoxia, alpha 2-adrenergic, and nitric oxide-dependent interactions on canine cerebral... 16876517 - Phacodynamics: an aspiration flow vs vacuum comparison. 8781447 - Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flow-cytometr... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-11 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-04 Completed Date: 2011-03-17 Revised Date: 2012-02-01 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 560-71 Citation Subset: IM |
Affiliation:
|
Department of Neuroradiology, National Neuroscience Institute, Singapore, Singapore. yiching.lynn.ho@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Algorithms Carbon Dioxide / blood Cerebral Arteries / physiology*, physiopathology* Cerebrovascular Circulation / physiology* Data Interpretation, Statistical Female Humans Hypercapnia / physiopathology* Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Microcirculation / physiology Oxygen Consumption / physiology Photic Stimulation* Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffi...
Next Document: Tumor necrosis factor ? primes cerebral endothelial cells for erythropoietin-induced angiogenesis.