| Similarities and differences of human and experimental mouse lymphangiomas. | |
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MedLine Citation:
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PMID: 17879316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lymphangioma is a disfiguring malformation of early childhood. A mouse lymphangioma model has been established by injecting Freund's incomplete adjuvant (FIA) intraperitoneally, but has not been compared with the human disease. We show that, in accordance with studies from the 1960s, the mouse model represents an oil-granuloma, made up of CD45-positive leukocytes and invaded by blood and lymph vessels. Several markers of lymphatic endothelial cells are expressed in both mouse and human, like CD31, Prox1, podoplanin, and Lyve-1. However, the human disease affects all parts of the lymphovascular tree. We observed convolutes of lymphatic capillaries, irregularly formed collectors with signs of disintegration, and large lymph cysts. We observed VEGFR-2 and -3 expression in both blood vessels and lymphatics of the patients, whereas in mouse VEGFR-2 was confined to activated blood vessels. The experimental mouse FIA model represents a vascularized oil-granuloma rather than a lymphangioma and reflects the complexity of human lymphangioma only partially. |
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Authors:
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Philipp Kasten; Gerrit Schnöink; Astrid Bergmann; Maria Papoutsi; Kerstin Buttler; Jochen Rössler; Herbert A Weich; Jörg Wilting |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 236 ISSN: 1058-8388 ISO Abbreviation: Dev. Dyn. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2008-01-09 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 2952-61 Citation Subset: IM |
Copyright Information:
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2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Anatomy and Cell Biology, Georg-August-University, Goettingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD31 / metabolism* Biological Markers / metabolism Disease Models, Animal* Endothelium, Lymphatic / pathology Freund's Adjuvant Granuloma / metabolism, pathology Humans Infant Lymphangioma* / blood supply, metabolism, pathology Lymphatic Vessels / pathology Male Mice Mice, Inbred BALB C Vascular Endothelial Growth Factor Receptor-2 / metabolism Vascular Endothelial Growth Factor Receptor-3 / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-6-2915/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD31; 0/Biological Markers; 9007-81-2/Freund's Adjuvant; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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