Document Detail

Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects.
MedLine Citation:
PMID:  22369859     Owner:  NLM     Status:  MEDLINE    
We have reviewed effects of long chain (LC) n-3 PUFA on markers of atherosclerosis in human subjects with a focus on individual effects of EPA and DHA. Initial results from epidemiological studies suggested that LC n-3 PUFA from fish oils (FO) reduced incidence of CVD; those results have been confirmed in interventional studies. Dietary intervention with n-3 PUFA decreased fasting and postprandial TAG, number of remnant-like chylomicron particles, large VLDL, and total and small dense LDL particles. It increased mean size of LDL particles by increasing number of large and decreasing those of small dense particles. With some exceptions, n-3 PUFA decreased blood pressure (BP) and heart rate (HR), flow-mediated dilation (FMD) and plasma concentrations of inflammatory markers. n-3 PUFA also decreased circulating adhesion molecules and intima-media thickness (IMT) in some but not other studies. For IMT, results varied with the sex and artery being examined. EPA effects on FMD are endothelial cell dependent, while those of DHA seem to be endothelial cell independent. Individually, both EPA and DHA decreased TAG and inflammatory markers, but only DHA decreased HR, BP and number of small dense LDL particles. Results varied because of dose and duration of n-3 PUFA, EPA:DHA, health status of subjects and other reasons. Future studies are needed to determine optimal doses of EPA and DHA individually, their synergistic, additive or antagonistic effects, and to understand underlying mechanisms. In conclusion, n-3 PUFA decreased several risk factors for atherosclerosis without any serious adverse effects.
Darshan S Kelley; Yuriko Adkins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-02-28
Journal Detail:
Title:  The Proceedings of the Nutrition Society     Volume:  71     ISSN:  1475-2719     ISO Abbreviation:  Proc Nutr Soc     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-07     Completed Date:  2012-08-23     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7505881     Medline TA:  Proc Nutr Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-31     Citation Subset:  IM    
Western Human Nutrition Research Center, ARS, USDA, Department of Nutrition, University of California Davis, CA 95616, USA.
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MeSH Terms
Atherosclerosis / blood,  etiology,  prevention & control*
Biological Markers / blood
Blood Pressure / drug effects*
Carotid Intima-Media Thickness
Chylomicrons / blood
Dietary Fats / pharmacology,  therapeutic use
Docosahexaenoic Acids / pharmacology*,  therapeutic use
Eicosapentaenoic Acid / pharmacology*,  therapeutic use
Endothelium, Vascular / cytology,  drug effects*,  pathology
Fish Oils / pharmacology,  therapeutic use
Heart Rate / drug effects*
Inflammation Mediators / metabolism
Lipids / blood*
Reg. No./Substance:
0/Biological Markers; 0/Chylomicrons; 0/Dietary Fats; 0/Fish Oils; 0/Inflammation Mediators; 0/Lipids; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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