Document Detail

Similarities between Brugada syndrome and ischemia-induced ST-segment elevation. Clinical correlation and synergy.
MedLine Citation:
PMID:  16226069     Owner:  NLM     Status:  MEDLINE    
Vasospastic angina (VSA) and Brugada syndrome (BS) are classified into different categories of cardiac disease, but both can be causes of sudden cardiac death from ventricular fibrillation (VF). The coexistence of VSA and BS in the same patient is possible, and this raises several questions: (1) what is the incidence of the coexistence of BS and VSA in the same patient? (2) is susceptibility to VF enhanced by the coexistence of the 2 diseases? and (3) is there any possibility of Ca-antagonists being used for the treatment of VSA-aggravated BS? In our institution, VSA coexisted in 5 of the 38 patients with BS (13.1%). Anginal episodes were confirmed clinically in 4 of the 5 patients, and syncope attack occurred after the symptom of chest pain in 2 patients. However, VF did not develop during the coronary vasospasm in any of the patients. Treatment with Ca-antagonist was effective for VSA, and neither aggravation of Brugada-type electrocardiographic abnormality nor an increase in the incidence of syncope attack was observed. Although the coexistence of BS and VSA in the same patient is not rare, neither enhanced susceptibility to VF nor the proarrhythmic effect of Ca-antagonist has been confirmed in our experience. However, careful attention is required in such patients because the influence of myocardial ischemia and/or the effect of Ca-antagonist may be different in each patient with BS.
Masaomi Chinushi; Hiroshi Furushima; Yasutaka Tanabe; Takashi Washizuka; Yoshifusa Aizawaz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  38     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-17     Completed Date:  2006-04-13     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18-21     Citation Subset:  IM    
Department of Medical Technology, School of Health Science, Niigata University School of Medicine, Niigata 951-8518, Japan.
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MeSH Terms
Bundle-Branch Block / complications,  diagnosis*,  drug therapy,  physiopathology*
Calcium Channel Blockers / therapeutic use
Coronary Vasospasm / diagnosis
Diagnosis, Differential
Heart Conduction System / physiopathology*
Middle Aged
Myocardial Ischemia / complications,  diagnosis*,  drug therapy,  physiopathology*
Tachycardia, Ventricular / drug therapy,  etiology
Ventricular Fibrillation / drug therapy,  etiology
Reg. No./Substance:
0/Calcium Channel Blockers

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