Document Detail


Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans.
MedLine Citation:
PMID:  17991697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Low-volume 'sprint' interval training (SIT) stimulates rapid improvements in muscle oxidative capacity that are comparable to levels reached following traditional endurance training (ET) but no study has examined metabolic adaptations during exercise after these different training strategies. We hypothesized that SIT and ET would induce similar adaptations in markers of skeletal muscle carbohydrate (CHO) and lipid metabolism and metabolic control during exercise despite large differences in training volume and time commitment. Active but untrained subjects (23 +/- 1 years) performed a constant-load cycling challenge (1 h at 65% of peak oxygen uptake (.VO(2peak)) before and after 6 weeks of either SIT or ET (n = 5 men and 5 women per group). SIT consisted of four to six repeats of a 30 s 'all out' Wingate Test (mean power output approximately 500 W) with 4.5 min recovery between repeats, 3 days per week. ET consisted of 40-60 min of continuous cycling at a workload that elicited approximately 65% (mean power output approximately 150 W) per day, 5 days per week. Weekly time commitment (approximately 1.5 versus approximately 4.5 h) and total training volume (approximately 225 versus approximately 2250 kJ week(-1)) were substantially lower in SIT versus ET. Despite these differences, both protocols induced similar increases (P < 0.05) in mitochondrial markers for skeletal muscle CHO (pyruvate dehydrogenase E1alpha protein content) and lipid oxidation (3-hydroxyacyl CoA dehydrogenase maximal activity) and protein content of peroxisome proliferator-activated receptor-gamma coactivator-1alpha. Glycogen and phosphocreatine utilization during exercise were reduced after training, and calculated rates of whole-body CHO and lipid oxidation were decreased and increased, respectively, with no differences between groups (all main effects, P < 0.05). Given the markedly lower training volume in the SIT group, these data suggest that high-intensity interval training is a time-efficient strategy to increase skeletal muscle oxidative capacity and induce specific metabolic adaptations during exercise that are comparable to traditional ET.
Authors:
Kirsten A Burgomaster; Krista R Howarth; Stuart M Phillips; Mark Rakobowchuk; Maureen J Macdonald; Sean L McGee; Martin J Gibala
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-08
Journal Detail:
Title:  The Journal of physiology     Volume:  586     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-02     Completed Date:  2008-05-19     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-60     Citation Subset:  IM    
Affiliation:
Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / physiology*
Adult
Biopsy
Carbohydrate Metabolism / physiology
Energy Metabolism / physiology*
Exercise / physiology*
Exercise Test
Female
Heat-Shock Proteins / metabolism
Humans
Lipid Metabolism / physiology
Male
Muscle, Skeletal / enzymology,  pathology
Oxygen Consumption / physiology
Physical Endurance / physiology*
Time Factors
Transcription Factors / metabolism
Chemical
Reg. No./Substance:
0/Heat-Shock Proteins; 0/PPARGC1A protein, human; 0/Transcription Factors
Comments/Corrections
Comment In:
J Physiol. 2008 Jan 1;586(1):1-2   [PMID:  18167367 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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