Document Detail

Similar level of impairment in exercise performance and oxygen uptake kinetics in middle-aged men and women with type 2 diabetes.
MedLine Citation:
PMID:  22538515     Owner:  NLM     Status:  Publisher    
The present study tested the hypothesis that the magnitude of the type 2 diabetes-induced impairments in peak VO(2) and VO(2) kinetics would be greater in females than males in middle-aged participants. Thirty-two individuals with type 2 diabetes (16 male, 16 female), and 32 age- and BMI-matched healthy individuals (16 male, 16 female) were recruited. Initially, the ventilatory threshold (VT) and peak VO(2) were determined. On a separate day, subjects completed four 6-minute bouts of constant-load cycling at 80% VT for the determination of VO(2) kinetics using standard procedures. Cardiac output (CO) (inert gas rebreathing) was recorded at rest, 30 and 240 seconds during two additional bouts. Peak VO(2) ( was significantly reduced in men and women with type 2 diabetes compared with their respective non-diabetic counterparts (men, 27.8±4.4 vs. 31.1±6.2; women, 19.4±4.1 vs. 21.4±2.9). The time constant (s) of phase 2 (τ(2)) and mean response time (s) of the VO(2) response (MRT) were slowed in women with type 2 diabetes compared with healthy women (τ(2), 43.3±9.8 vs. 33.6±10.0; MRT, 51.7±9.4 vs. 43.5±11.4) and in men with type 2 diabetes compared with non-diabetic men (τ(2), 43.8±12.0 vs. 35.3±9.5; MRT, 57.6±8.3 vs. 47.3±9.3). The magnitude of these impairments was not different between males and females. The steady state CO responses or the dynamic responses of CO were not affected by type 2 diabetes among men or women. The results suggest that the type 2 diabetes-induced impairments in peak VO(2) and VO(2) kinetics are not affected by sex in middle aged participants.
Eamonn O'Connor; Catherine Kiely; Donal O'Shea; Simon Green; Mikel Egana
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-25
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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