Document Detail


Similar alterations of lymphocyte subpopulations in type I and type II diabetes.
MedLine Citation:
PMID:  8377873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood lymphocytes of diabetes mellitus patients were analyzed by flow-cytometry using monoclonal antibodies directed against cell surface markers present in T- and B-cells, monocytes and natural killer cells. The lymphocyte subsets were quantified and expressed in an absolute amount. The study included 17 patients with type I (insulin-dependent), 21 patients with type II (non-insulin-dependent) diabetes and 40 age-matched control subjects. Quantification of the cells present within different lymphocyte subsets revealed a general increase in both patient groups compared to their controls, with the exception of activated T-cells. However, no significant difference was found in the relative amount of T-helper cells and T-suppressor/cytotoxic cells of the diabetes patients when they were compared with their control groups. The fact that we found similar changes in lymphocyte subsets in both type I and type II diabetes suggests that the altered immunological state is secondary to the diabetes mellitus in general.
Authors:
P F Spooren; I Vermes; J W Soons
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  42     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Medisch Spectrum Twente, Enschede, Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Case-Control Studies
Diabetes Mellitus, Type 1 / blood*,  immunology*,  metabolism
Diabetes Mellitus, Type 2 / blood*,  immunology*,  metabolism
Female
Humans
Immunophenotyping
Killer Cells, Natural
Lymphocyte Subsets*
Male
Matched-Pair Analysis
Middle Aged
Monocytes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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