Document Detail


Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis.
MedLine Citation:
PMID:  23337479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Psychiatric comorbidity is common in Crohn's disease (CD) and ulcerative colitis (UC). Inflammatory bowel disease (IBD)-related surgery or hospitalizations represent major events in the natural history of the disease. The objective of this study is to examine whether there is a difference in the risk of psychiatric comorbidity following surgery in CD and UC.
METHODS: We used a multi-institution cohort of IBD patients without a diagnosis code for anxiety or depression preceding their IBD-related surgery or hospitalization. Demographic-, disease-, and treatment-related variables were retrieved. Multivariate logistic regression analysis was performed to individually identify risk factors for depression and anxiety.
RESULTS: Our study included a total of 707 CD and 530 UC patients who underwent bowel resection surgery and did not have depression before surgery. The risk of depression 5 years after surgery was 16% and 11% in CD and UC patients, respectively. We found no difference in the risk of depression following surgery in the CD and UC patients (adjusted odds ratio, 1.11; 95% confidence interval, 0.84-1.47). Female gender, comorbidity, immunosuppressant use, perianal disease, stoma surgery, and early surgery within 3 years of care predicted depression after CD surgery; only the female gender and comorbidity predicted depression in UC patients. Only 12% of the CD cohort had ≥4 risk factors for depression, but among them nearly 44% subsequently received a diagnosis code for depression.
CONCLUSIONS: IBD-related surgery or hospitalization is associated with a significant risk for depression and anxiety, with a similar magnitude of risk in both diseases.
Authors:
Ashwin N Ananthakrishnan; Vivian S Gainer; Tianxi Cai; Raul Guzman Perez; Su-Chun Cheng; Guergana Savova; Pei Chen; Peter Szolovits; Zongqi Xia; Philip L De Jager; Stanley Shaw; Susanne Churchill; Elizabeth W Karlson; Isaac Kohane; Roy H Perlis; Robert M Plenge; Shawn N Murphy; Katherine P Liao
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-22
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  108     ISSN:  1572-0241     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-04     Completed Date:  2013-06-04     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  594-601     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anxiety Disorders / epidemiology,  etiology*
Cohort Studies
Colitis, Ulcerative / complications,  psychology,  surgery*
Crohn Disease / complications,  psychology,  surgery*
Depressive Disorder / epidemiology,  etiology*
Female
Hospitalization*
Humans
Logistic Models
Male
Middle Aged
Postoperative Complications*
Risk Factors
Sex Factors
Grant Support
ID/Acronym/Agency:
K08 AR060257/AR/NIAMS NIH HHS; K08 AR060257/AR/NIAMS NIH HHS; K08 NS079493/NS/NINDS NIH HHS; K23 DK097142/DK/NIDDK NIH HHS; K23 DK097142/DK/NIDDK NIH HHS; K24 AR052403/AR/NIAMS NIH HHS; K24 AR052403/AR/NIAMS NIH HHS; P60 AR047782/AR/NIAMS NIH HHS; R01 AR049880/AR/NIAMS NIH HHS; R01 AR049880/AR/NIAMS NIH HHS; R01 AR057108/AR/NIAMS NIH HHS; R01 AR059648/AR/NIAMS NIH HHS; R01-AR056768/AR/NIAMS NIH HHS; R01-AR059648/AR/NIAMS NIH HHS; U01 GM092691/GM/NIGMS NIH HHS; U01-GM092691/GM/NIGMS NIH HHS; U54 LM008748/LM/NLM NIH HHS; U54-LM008748/LM/NLM NIH HHS
Comments/Corrections

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