Document Detail


Similar Reference Intervals for Total Testosterone in Healthy Young and Elderly Men. Results from the Odense Androgen Study.
MedLine Citation:
PMID:  23106255     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CONTEXT: Aging in men is associated with changes in levels of sex hormones. OBJECTIVE: To evaluate differences in sex hormones in young and elderly men and the significance of comorbidity and fat mass on sex hormones in elderly men. DESIGN: Cross-sectional. PATIENTS: 783 men aged 20-29 years and 600 men aged 60-74 years randomly recruited from the background population. MEASUREMENTS: Sex hormones and SHBG were measured, and reference intervals were determined in healthy individuals in both groups and in elderly men stratified according to whether they were obese or lean (waist-circumference ≥102cm). RESULTS: Sex hormones were lower and SHBG higher in elderly men compared to the young cohort. Lower cut-offs for TT in healthy, young and elderly men were similar (Lower cut-off (95%CI): Young: 11.7 (11.2-12.1) vs. elderly: 11.2 (10.3-12.1) nmol/l), but lower and higher cut-offs of BT and FT were higher in young men. Higher levels of androgens were found in healthy elderly men compared to those with a chronic disease or obesity. Androgens were inversely associated with central fat mass (CFM) whereas SHBG was inversely and directly associated with CFM and lower extremity fat mass (LEFM), respectively, in both young and elderly men. CONCLUSION: Reference intervals for TT were comparable in healthy young and elderly men, but reference intervals for FT and BT were lower in elderly men due to higher levels of SHBG. Androgens and SHBG were lower in elderly men with chronic disease and inversely associated with CFM. © 2012 Blackwell Publishing Ltd.
Authors:
M Frost; K Wraae; Tl Nielsen; Dm Hougaard; K Brixen; C Hagen; M Andersen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-25
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Endocrinology, Odense University Hospital Odense, Denmark.
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