| Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. | |
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MedLine Citation:
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PMID: 17195045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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: We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The naïve B cells of nearly all SLE and ANCA-SVV patients express approximately 20% less CD19 than healthy control (HC) B cells. In contrast, a subset of memory B cells of some SLE and ANCA-SVV Pts (25-35%) express two to fourfold more CD19 than HC B cells. These CD19(hi) memory B cells are activated and exhibit evidence of antigen selection. Proteome array analysis of 67 autoantigens indicates that CD19(hi) SLE Pts exhibit a distinct autoantibody profile characterized by high levels of antibodies to small nuclear ribonucleoproteins and low levels of antiglomerular autoantibodies. These findings have implications for autoreactive B-cell activation and suggest a shared mechanism of B-cell tolerance loss in these two diseases. |
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Authors:
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Donna A Culton; Matilda W Nicholas; Donna O Bunch; Quan Li Zhen; Thomas B Kepler; Mary Anne Dooley; Chandra Mohan; Patrick H Nachman; Stephen H Clarke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-12-29 |
Journal Detail:
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Title: Journal of clinical immunology Volume: 27 ISSN: 0271-9142 ISO Abbreviation: J. Clin. Immunol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-08 Completed Date: 2007-05-08 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 53-68 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antineutrophil Cytoplasmic / immunology* Antigens, CD19 / immunology* Autoantibodies / analysis Autoimmune Diseases* B-Lymphocyte Subsets / immunology B-Lymphocytes / immunology* Female Flow Cytometry Glomerulonephritis / immunology Humans Immune Tolerance Lupus Erythematosus, Systemic / immunology* Lupus Nephritis / immunology Lymphocyte Activation Male Middle Aged Protein Array Analysis / methods Vasculitis / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI29576/AI/NIAID NIH HHS; AI43587/AI/NIAID NIH HHS; DK58335/DK/NIDDK NIH HHS; T32 AR07369/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; 0/Antigens, CD19; 0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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