Document Detail


Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.
MedLine Citation:
PMID:  17195045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
: We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The naïve B cells of nearly all SLE and ANCA-SVV patients express approximately 20% less CD19 than healthy control (HC) B cells. In contrast, a subset of memory B cells of some SLE and ANCA-SVV Pts (25-35%) express two to fourfold more CD19 than HC B cells. These CD19(hi) memory B cells are activated and exhibit evidence of antigen selection. Proteome array analysis of 67 autoantigens indicates that CD19(hi) SLE Pts exhibit a distinct autoantibody profile characterized by high levels of antibodies to small nuclear ribonucleoproteins and low levels of antiglomerular autoantibodies. These findings have implications for autoreactive B-cell activation and suggest a shared mechanism of B-cell tolerance loss in these two diseases.
Authors:
Donna A Culton; Matilda W Nicholas; Donna O Bunch; Quan Li Zhen; Thomas B Kepler; Mary Anne Dooley; Chandra Mohan; Patrick H Nachman; Stephen H Clarke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-29
Journal Detail:
Title:  Journal of clinical immunology     Volume:  27     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-05-08     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-68     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antineutrophil Cytoplasmic / immunology*
Antigens, CD19 / immunology*
Autoantibodies / analysis
Autoimmune Diseases*
B-Lymphocyte Subsets / immunology
B-Lymphocytes / immunology*
Female
Flow Cytometry
Glomerulonephritis / immunology
Humans
Immune Tolerance
Lupus Erythematosus, Systemic / immunology*
Lupus Nephritis / immunology
Lymphocyte Activation
Male
Middle Aged
Protein Array Analysis / methods
Vasculitis / immunology*
Grant Support
ID/Acronym/Agency:
AI29576/AI/NIAID NIH HHS; AI43587/AI/NIAID NIH HHS; DK58335/DK/NIDDK NIH HHS; T32 AR07369/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Antigens, CD19; 0/Autoantibodies

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