Document Detail


Simian immunodeficiency virus (SIV) from sun-tailed monkeys (Cercopithecus solatus): evidence for host-dependent evolution of SIV within the C. lhoesti superspecies.
MedLine Citation:
PMID:  10438863     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently we reported the characterization of simian immunodeficiency virus (SIVlhoest) from a central African l'hoest monkey (Cercopithecus lhoesti lhoesti) that revealed a distant relationship to SIV isolated from a mandrill (SIVmnd). The present report describes a novel SIV (SIVsun) isolated from a healthy, wild-caught sun-tailed monkey (Cercopithecus lhoesti solatus), another member of the l'hoest superspecies. SIVsun replicated in a variety of human T-cell lines and in peripheral blood mononuclear cells of macaques (Macaca spp.) and patas monkeys (Erythrocebus patas). A full-length infectious clone of SIVsun was derived, and genetic analysis revealed that SIVsun was most closely related to SIVlhoest, with an amino acid identity of 71% in Gag, 73% in Pol, and 67% in Env. This degree of similarity is reminiscent of that observed between SIVagm isolates from vervet, grivet, and tantalus species of African green monkeys. The close relationship between SIVsun and SIVlhoest, despite their geographically distinct habitats, is consistent with evolution from a common ancestor, providing further evidence for the ancient nature of the primate lentivirus family. In addition, this observation leads us to suggest that the SIVmnd lineage should be designated the SIVlhoest lineage.
Authors:
B E Beer; E Bailes; R Goeken; G Dapolito; C Coulibaly; S G Norley; R Kurth; J P Gautier; A Gautier-Hion; D Vallet; P M Sharp; V M Hirsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  73     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-07     Completed Date:  1999-09-07     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7734-44     Citation Subset:  IM; X    
Affiliation:
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF131870
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
CD4-Positive T-Lymphocytes / cytology
Cell Line
Cercopithecus / virology*
Cross Reactions
DNA, Viral
Evolution, Molecular*
Female
Humans
Lentivirus
Male
Molecular Sequence Data
Sequence Homology, Amino Acid
Simian immunodeficiency virus / classification,  genetics*
Tumor Cells, Cultured
U937 Cells
Chemical
Reg. No./Substance:
0/DNA, Viral
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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